Fonds documents J.B. Johnston's professional activities from 1839 to 1859. It also includes his medical thesis De delirio tremente, Edinburgh, 1833. The fonds contains a logbook with notes, summaries of readings, reports of unusual medical cases and obstetrical list, and his medical thesis.

The fonds illustrates Dr. Cone's work as a neurosurgeon and consists of correspondence, letters, articles, newspaper clippings, obituaries, photographs, slides, research material and notes, course material, annual reports, manuscripts, typescripts, annotations, published and unpublished manuscripts written by Dr. Cone, printed copies of articles, and patient files.