The bulk of Girdwood's papers concern his work in forensic medicine. Other materials cover his research in photography, and his general medical and scientific interests. Girdwood's career as medical-legal consultant is documented by 24 cm of his notes and reports, together with some correspondence, on four poisoning trials: People vs Emma Davis (Malone, N.Y., 1881), Queen vs Provencher and Boisclair (Sorel, 1867), Queen vs Joseph Ruel (St. Hyacinthe, 1868), and Queen vs David Prevost and Damase Brunet (L'Orignal, 1881). There are also coroner's autopsy reports and notes for four cases; Girdwood's memoires of ten cases on which he served as consultant; Rogers and Girdwood's submission to the Home Office, London, on the strychnine test, together with letters to Lancet and the Times on the same subject; and notes on the counterfeiting of stamps (1893). His interest in medical photography is reflected in lists of X-rays taken by him (1898-1899) and reprints of three articles. His general scientific and medical activities are represented by a scrapbook of newsclippings on cholera (1854), a lecture on gold presented to the Natural History Society of Montréal (n.d.), essays on strychnine (1864) and water filtration (1869), a review of a textbook in physiology (1864) and some reprints, including convocation addresses to the Medical Faculty. Finally, there is a manuscript copy of an address to the graduating class of Applied Science in 1881 and a small scrapbook of printed articles by Girdwood's father, G.F. Girdwood, M.D.

The collection consists of fifteen volumes, primarily manuscript with some printed, containing over 1,300 culinary and medical handwritten recipes, plus numerous loose recipes also mainly manuscript. The documents in the collection originated chiefly from the Doncaster area of South Yorkshire, centred on Hooten Pagnell Hall. Many of the manuscripts and notes are signed by or addressed to Sarah Anne Warde. Series 1 comprises the fifteen bound volumes, two of which are printed works by female authors, while the remaining thirteen are manuscript notebooks. Two of these manuscript notebooks are attributed to Sarah Anne Warde, while one is attributed to Eliza Smithson. The manuscript attributed to Eliza Smithson contains table setting riddles (also known as an enigmatical bill of fare). Loose recipes are found in Series 2. This series consists of approximately 300 culinary, medical, and household recipes dating from roughly the 1780s through the 1850s.

The fonds consists primarily of Logan's scientific work. A small percentage relates to the affairs of his family and to memorials to Logan after his death. The great majority of the papers consists of scientific correspondence from about 1820 to 1874, but mostly for the years following his appointment to the Survey in 1842. The letters deal with the collection, exchange and description of geological specimens, expeditions under the aegis of the survey, problems of research and scientific interpretation, scientific meetings, and visits by scientists. The number of correspondents, both individuals and learned societies, is very large, but the most substantial bodies of letters are from J.W. Dawson, geologist and Principal of McGill University, James Hall, paleontologist of the New York Geological Survey, Alexander Murray, Logan's chief assistant, and James Lowe of Grenville, Québec, who supplied Logan with specimens and appears to have been casually employed by him on surveying jobs and field trips. Other correspondents include Sanford Fleming, E.D. Ashe of the Québec Observatory, Thomas Sterry Hunt, and R.I. Murchison of the Geographical Society of Great Britain. Some letters pertain to political or social affairs, but usually in close connection with the scientific work of Logan or the Survey. These files contain copies of some of Logan's outgoing letters, as well as some letters addressed to other individuals, generally his assistants. Other scientific papers consist of field trip records (a journal kept during an expedition in 1845, a weather table kept on Lake Superior in the winter of 1846-1847, work records and astronomical readings for surveying projects, notes on mineral deposits, and lists of specimens), manuscripts of three scientific papers, as well as "Observations on the proposed Geological Survey", and manuscript and printed maps and geological schemata, including some by Logan of the Bay of Fundy, Labrador, and Hamilton, Ontario regions. Manuscript catalogues of specimens were prepared by Logan for the Paris Exhibitions of 1855 and 1867. Official reports include Logan's annual reports for 1842-1844, an overview of the work of the Geological Survey, 1866, two reports by Logan on prospects for mining on the north shore of Lake Superior, 1846, 1847, and one on mineral deposits around Rivière-du-Loup, 1853, as well as Logan's copy of his proposed Geological Survey Bill, 1844, and some copies of reports on mining and cartography prepared by others. Logan's financial records include expense accounts for Geological Survey expeditions, as well as other professional expenditures, such as books. His private and family life is reflected by a very brief diary of an Atlantic crossing in 1856, letters to and from his brothers James and Henry, his father, his uncle Hart Logan, and Hart Logan's partner John Fleming, covering the years 1772-1856. There are also baptismal and burial certificates, and legal documents, particularly bills of sale pertaining to James Logan's farm. Memorials to Logan after his death include J.W. Dawson's correspondence concerning the Logan Memorial Fund and Collection, 1881, and a manuscript biography by Alexander Murray. There is a chronological and author/recipient index to these papers.

Additional materials received from McGill Library's Rare Books and Special Collections consist of correspondence, 1837-1871; notices of admission to scientific and historical societies, 1842-1867; a history of the geological survey 1850; a report on mining locations addressed to B. Papineau, 1847; and correspondence with Robert Bell, 1861-1874.

The collection consists of documents amassed by Roderick Mackenzie. Among the Masson manuscripts there are other series of letters; as well as journals kept by North-Westers and various business documents. Some of this material exists as originals; others are contemporary copies - the George Keith letters for example are contemporary copies on paper watermarked 1827. The collection also includes some duplicate texts - contemporary copies or later nineteenth-century copies that in some cases represent edited versions of the texts. Samuel Wilcocke's account of the death of Benjamin Frobisher exists in a draft original (or contemporary copy) and in a late nineteenth-century clean copy. Of course Benjamin Frobisher did not die in the dramatic circumstances as recorded by Wilcocke, but peacefully in Quebec City in 1821.

Fonds consists of a manuscript of Mémoires de mathématique et de physique contenant un traité des épicycloïdes (published in Paris in 1674) and illustrated with mathematical diagrams.

Fonds consists of a late seventeenth-century manuscript containing a critical commentary on Machiavelli's The Price, created for the use of Agostino Cerretari.

The collection consists of four early Irish manuscripts assembled by the Montreal collector Edward Murphy as part of his private library. The manuscripts include a copy of The Midnight Court (Cúirt an mheán oíche) by Brian Merriman, the Life of St. Patrick by John Chambers, Tri Biorghaoithe an Bhais (Three shafts of death) by Geoffrey Keating, and a fragment of an Irish vocabulary (Nuadhfoclóir bogcruaideach).

Fonds consists of contemporary manuscript copies of various legal records and instruments relating to the Capacci family. Includes one manuscript written on parchment in pale brown ink, ruled in pale brown ink, and bound in full contemporary blind tooled calf with laid paper endpapers and remnants of ties on covers, as well as a smaller booklet, written on parchment glued into a laid paper wrapper. Documents appear to be dated between 1556 and 1583 and are written in Latin and Italian (sometimes alternating within document). The legal instruments appear chiefly related to the dowry of Orietta Capacci (the dowry is also referenced in an Italian note in a later hand (1650?) inside front cover). Some names found throughout the documents include Orietta Capacci (or Orietta de Capacci) and Annibale (or Anibal) Camillo de Capacci.

Fonds contains a manuscript, entitled "Remarks on the Osteology of Alexander Monro by himself", written by Dr. John George Bethune who transcribed an old damaged manuscript found in a trunk in the garret of the steam factory of Bethune's father in August 1848. The damaged manuscript was, according to Bethune, from one of three famous physicians, three successive generations of an Edinburgh family, who all bore the name Alexander Monro.

Fonds documents Dr. H.E. MacDermot's medical-historical activities. The fonds contains newspaper clippings, manuscript notes, photographs, lectures notes, and a draft of The MGH, the Years of Change.