The fonds consists chiefly of student notebooks kept by F. Clarke Fraser while an undergraduate at Acadia University during the late 1930s-1940. They represent a variety of subjects, including zoology, physics, mathematics, and biology. Two notebooks date from his Med IV year (1949-1950) at McGill University’s Faculty of Medicine, one with ophthalmology lab and clinical notes and reading and lecture notes, and one an obstetrical diary from the Montreal Maternity Hospital. Also included is a later reprint of an article (published 1957), loose notes, and a photograph of F. Clarke Fraser and a companion dining at the Montreal restaurant Au lutin qui bouffe, famous for its resident piglet, which restaurant-goers were often photographed holding and feeding.

The fonds contains correspondence related to the Osler Library and its holdings with people such as Maude Abbott, Edward Archibald, William B. Bean, Edward Horton Bensley, Archibald Malloch, Casey Wood, as well as John Farquhar Fulton, Keeper of the Medical History Collections at Yale University's library; the fonds also contains a typescript of talks by W.W. Francis (titled "Showman's Patter") about books and other items held in the Osler Library.

The fonds consists of books, letters, documents, drafts, publications, photographs, and several artifacts collected by W. W. Francis and Marian Francis Kelen over the course of their lifetimes. Many books and documents relate to Sir William Osler and the Osler family including several personal letters, the Deed of Trust documents regarding the Bibliotheca Osleriana, drafts of Osler's works, and a wooden travelling trunk that belonged to Edward Revere Osler. The fonds also includes original poetry written by Marian Osborne, W. W. Francis, and Marian Francis Kelen.

The fonds contains original and typescript letters, manuscript notes, newspaper clippings, journal extracts, reminiscences and more, assembled by Harvey Cushing chiefly between 1920 and 1924 during the course of his research for the biography of William Osler. For the biography, Cushing collected and retyped over 7500 pieces of Osler's correspondence, among which are some original letters.

The fonds is separated into three series: Manuscripts, Working Notes and Osler's Correspondence. It also contains photographs, annual reports, publications, clippings, one watercolor painting, one postcard. Osler's correspondence is further arranged in three subseries based chronologically.

The fonds consist of diaries, photographs, scrapbooks, photographs albums and ephemera created by or about Canadian nursing sister Clare Gass (1887-1968). A diary and a photograph album chronicle Clare Gass's experiences as a nurse with the Canadian Army Medical Corps stationed in France and England during the First World War. The diary contains entries dated between 4 March 1915 to 31 December 1916 and also features an early appearance of the poem "In Flanders Field," written by John McCrae during the war upon the burial of a close friend. It is copied out in the diary entry for 30 October, nearly six weeks before its first publication in the magazine Punch on 8 December 1915. The diary originally had ephemeral material originally laid in, including newspaper clippings, manuscript notes and letters, one photograph, pencil drawings, and ten dried plant specimens. These have been removed from the diary for preservation purposes. Her photograph album from the First World War begins in April 2015 with photos of the nursing sisters assembled for inspection before deployment and the sea crossing to Europe. The photographs include depictions of soldiers and nursing sisters, oftentimes in their huts, and hospital interiors from multiple hospitals at which she worked and visited. It contains photographs from various postings in Etaples, Camiers, Cliveden (England) Boulogne, and Rhyl (Wales), as well as landscapes, historical sites, and other scenes from the surrounding areas that she toured, including a trip to Scotland. Leaves 13 and 14 of the photograph album also contain the text of “In Flanders Field.”

Loose photographs also document Gass’s wartime experiences in France, as well the hospital at St. Anne de Bellevue, Quebec, and Gass's transit duties in the Rockies in 1919. A series of photographs are from the visit of the Prince of Wales to Quebec October and November of 1919. Other loose photographs also depict wounded veterans, as well as personal photographs, including a portrait of Clare Gass at age 13.

Her childhood is also documented in the fonds by a photograph album containing photos from her years attending Edgehill School. The photos date chiefly between 1904 and 1905 and depict school exteriors, interiors, friends and classmates, as well as school activities such as Drill Class.

An additional folder contains material compiled by Gertrude Henderson, including letters to Clare Gass, some of her writings, and other ephemera, such as clippings noting Gass’s retirement, sketches, some of Gass’s poetry and stories, a memorial from King George to those who served in the war, and manuscript notes on Gass’s school and word record, including years and places that she was stationed. The folder also contains assorted later photographs of Gass.

The Sir William Osler Collection, distinct from the Bibliotheca, is an extensive archival holding of Osler's correspondence (including eighteen hundred original letters), daybooks, accounts, engagement books, legal documents, book invoices, membership certificates, notebooks, lectures, addresses, newspaper clippings, photographs, books with manuscript additions, and miscellaneous loose items formerly inserted into individual books in his library. The collection also contains various family papers, including correspondence of Lady Grace Revere Osler and Edward Revere Osler.

Fonds contains diplomas, certificates from medical associations, and photographs relating to Robert Palmer Howard and Alan Campbell Palmer Howard.

Fonds consists of a manuscript translation by Dr. Gruner of volume II of the Canon of Medicine of Avicenna dated 1957 and vocabulary indexes of Arabic names of Materia Medica, Latin-English names, Latin-Arabic equivalents, native names and others. These vocabularies were done in 1929-1930. It also contains three volumes of Dr. Gruner's research on cancer. This work was done through the Archibald Cancer Research Fund, from 1932 to 1946. In volume III, a printed address "A Vagabond Cruise Round Cancer" (1950) is inserted in the cover.