Fonds contains William Wood Squire's manuscript of his thesis "Pathology and Treatment of some forms of Partial Paralysis" which won a prize as best thesis in medicine at McGill in 1864. The fonds includes a bound notebook and one loose illustration.

Papers consist of personal correspondence, including substantial family correspondence, diaries, journals, engagement books, ledgers, menus, manuscript poems, galley proofs, lecture notes, scrapbooks, and photographs. It includes correspondence, 1874-1935; a diary of Drummond's trip to Great Britain, 1902; dinner menus, 1902-1903; engagement books, 1902-1906; galley proofs, 1905-1911; Journal of Impressions kept at Savanna la Mar, Jamaica, Windsor and Montreal, 1903-1911; lecture notes taken at McGill, 1878-1882; ledgers containing financial entries and patients' accounts during Drummond's practice in Knowlton and Montreal, 1885-1889; notebooks containing manuscripts poems, drafts and clippings, 1894-1909; scrapbooks related to literary topics, including clippings about Drummond's public readings, and book reviews, 1854-1907 and scrapbooks related to Drummond's dogs, 1890-1907. There are also some papers of Mrs. W.H. Drummond, including a typescript of her Life of W.H. Drummond; and diaries recording her trips to United States and Canada, 1892, 1903.

The fonds shows W. G. Henry's activities as a medical student at the Toronto School of Medicine and then at the Faculty of Medicine, McGill University, from 1878-1883. The material consists of 18 printed cards made out in writing to W. G. Henry: 6 from the Toronto School of Medicine for the sessions 1878-79 and 1879-80 (1 proof of registration/lecture programme card, 5 admission tickets); 6 from the University of McGill College or Faculty of Medicine, 1880-1882 (4 admission tickets, a certification card, an initialed dissection examination card); 5 certification cards from the Montreal General Hospital, 1881-1883; an admission tickets for the "University Dispensary" (undated).

Fonds contains the admission cards of William Forrest for the Montreal Medical Institution Library, the Montreal General Hospital and the lecture of Anatomia Physiologia et Chirurgica of John Stephenson, in 1824-1825. The fonds includes three admission cards.

Fonds documents William B. Malloch's activities as a medical student at McGill and the links he kept with his alma mater, 1863-1870. The fonds contains admission cards, programmes, certificates, examination copies, newspaper clippings and an indenture of apprenticeship.

Fonds contains the letters of certification of William A. De Wolf Smith's attendance at medical courses at McGill University in 1883. The fonds includes three letters of certification signed by teachers.

Fonds shows Thomas W. Reynolds' activities as a medical student through his admission tickets for his complete medical formation. It contains 39 admission cards signed by or printed for the teachers, among them William Osler.

Fonds shows T.F. Cotton's activities as a student at McGill University, 1903-1909. The fonds contains 24 bound notebooks with lectures notes taken by Cotton, 1903-1909, for courses in Medicine, Political Science, History, French Literature, English Composition and Literature. There is also a case book containing electrocardiograms and a volume of ophthalmology lecture notes bearing the name George C. Hale.

The Sir William Osler Collection, distinct from the Bibliotheca, is an extensive archival holding of Osler's correspondence (including eighteen hundred original letters), daybooks, accounts, engagement books, legal documents, book invoices, membership certificates, notebooks, lectures, addresses, newspaper clippings, photographs, books with manuscript additions, and miscellaneous loose items formerly inserted into individual books in his library. The collection also contains various family papers, including correspondence of Lady Grace Revere Osler and Edward Revere Osler.