The collection contains private records and papers relating to the medical and teaching career of Maude Abbott. It consists in large part of correspondence, 1894-1920, including family correspondence with, among others, her sister Alice Abbott, 1904-1919, and her brother Rev. Harry M. Babin, 1916-1920. Also included are manuscripts and drafts of articles and addresses; case reports; post-mortem records; glass slides and drawings; exhibit panels largely pertaining to her research on congenital heart disease; programmes of medical meetings, 1902-1937; reprints and papers relating to the history of medicine in Montreal and Quebec, as well as to the history of McGill, 1829-1936. In addition, there are photographs, some poems, an autobiographical sketch and a printed copy of her Classified and Annotated Bibliography of Sir William Osler's Publications, 1939, with corrections and annotations by W. W. Francis. Fonds also includes a draft of Abbott's letter to the Dean of Faculty of Medicine, McGill University, regarding admission (1889).

The fonds largely document Dr. Segall's professional activities as a cardiologist. It contains correspondence, notes, experimental notebooks, lecture notes, articles, speeches, patients' records, electrocardiograms, reprints and material pertaining to the Louis Gross Memorial Lectures, 1922-1979. Also included are several electrocardiograph machines, dictation devices, and audio recordings (reel-to-reel tapes, dictation disks, and cassette tapes). In addition, the fonds contain records of Dr. Segall's personal and family correspondence, financial transactions, and various other official and unofficial documents.

Fonds documents Dr. H.E. MacDermot's medical-historical activities. The fonds contains newspaper clippings, manuscript notes, photographs, lectures notes, and a draft of The MGH, the Years of Change.

Fonds shows Dr. D. Sclater Lewis' medical and medical-historical activities, from 1904 until his death. The fonds contains correspondence, lecture notes and notes for addresses and published papers.

The Sir William Osler Collection, distinct from the Bibliotheca, is an extensive archival holding of Osler's correspondence (including eighteen hundred original letters), daybooks, accounts, engagement books, legal documents, book invoices, membership certificates, notebooks, lectures, addresses, newspaper clippings, photographs, books with manuscript additions, and miscellaneous loose items formerly inserted into individual books in his library. The collection also contains various family papers, including correspondence of Lady Grace Revere Osler and Edward Revere Osler.

The fonds documents mainly Babkin's professional interests in physiology, especially glandular secretions and the nervous system. The fonds contains correspondence; lecture notes; citations; research notes and papers, including manuscripts sent to him by his colleagues; reprints of scientific articles mainly in Russian; and material used in the preparation of the biography of Ivan Pavlov. The latter contains correspondence with Ivan Petrovich Pavlov and members of his family, 1923-1948; photographs and portraits; and an unabridged typescript copy of Parts 1-3 of Pavlov: a Biography, with manuscript corrections, 1943-1946.

The fonds includes American Neurological Association material (1934-1941), army files (1939-1943), correspondence, lecture notes, glass slides, large glass negatives, colour screen filters, and reprints with a card index.

The fonds documents A.D. Blackader's personal and professional life. The fonds contains correspondence, diaries, autobiographical notes, papers and lectures, certificates, diplomas, testimonials, article reprints, photographs, and some memorabilia.

Fonds shows H.R. Griffith's papers and records pertaining to his introduction of the homeopathic remedy curare into anesthesia. The fonds contains correspondence, case records, and reprints, as well as the minute book of the Montreal Homoeopathic Association, 1863-1968.

The fonds includes Dr. Archibald’s correspondence and reports pertaining to the Ministry of National Defence, 1940-1945; certificates and diplomas; and a photograph. The correspondents include family members, Dr. John McCrae and Sir William Osler. There is also a draft of a book on wound ballistics and gas gangrene; an Army Field Service book, 1916 and two notebooks on internal and external pathology, “matiere medicale et therapeutique,” and “medecine legale et toxicologie,” 1895.