Fonds documents J.B. Johnston's professional activities from 1839 to 1859. It also includes his medical thesis De delirio tremente, Edinburgh, 1833. The fonds contains a logbook with notes, summaries of readings, reports of unusual medical cases and obstetrical list, and his medical thesis.

The fonds contains Dr. Jacques' journal of medical accounts receivable entered in an account book issued with blank pages and bound in half suede with green cloth boards. The account book was kept between November 1879 and January 1881. A title handwritten on a paper label on the cover reads "Journal pour 1879-1880-1881." The author's full name comes from within the journal (L. A. George Jacques, M. D.) and from Lovell's Montreal directory for 1881-1882 (Louis A. George Jacques, M. D.). Laid in at p. 207 is an ink blotter featuring pharmaceutical advertising for Glyco-Heroin (Smith).

Fonds contains the correspondence of James Bruce, Lord Eighth Earl of Elgin, with Dr. Michael McCulloch concerning his wife's confinements.

Fonds consists of correspondence with the pediatrician Dr. Alton Goldbloom of Montreal. It gives a picture of pediatrics and parental concerns at the time. The fonds contains 30 letters.

The fonds illustrates Dr. Cone's work as a neurosurgeon and consists of correspondence, letters, articles, newspaper clippings, obituaries, photographs, slides, research material and notes, course material, annual reports, manuscripts, typescripts, annotations, published and unpublished manuscripts written by Dr. Cone, printed copies of articles, and patient files.