The fonds largely document Dr. Segall's professional activities as a cardiologist. It contains correspondence, notes, experimental notebooks, lecture notes, articles, speeches, patients' records, electrocardiograms, reprints and material pertaining to the Louis Gross Memorial Lectures, 1922-1979. Also included are several electrocardiograph machines, dictation devices, and audio recordings (reel-to-reel tapes, dictation disks, and cassette tapes). In addition, the fonds contain records of Dr. Segall's personal and family correspondence, financial transactions, and various other official and unofficial documents.

The collection consists of documents pertaining to Dr. H. S. Birkett's medical activities, including 117 bound volumes of patient records (1889-1942), medical notebooks (1893-1896), bound RVH reports (1894-1938), RVH charts (1901-1920) and registers (1899-1917). There are also various letters addressed to Mr. and Mrs. Birkett, a manuscript, newspaper clippings, various degrees and medical association certificates, as well as photographs of H. S. Birkett's personal life and professional life at McGill and elsewhere. The collection also includes various artifacts collected by H. S. B, including military and medical memorabilia collected by H. S. Birkett.