Louisa Goddard Frothingham Molson was born on April 15, 1827, in Montreal, Canada.

She was a philanthropist and administrator of charities. She was an active manager of the Montreal Protestant Orphan Asylum for 64 years. Well-educated, intelligent, and possessing a strong character, she was sure of her abilities and was both a dedicated worker and a leader in policy decisions. She was also a manager and honorary manager of the Protestant Infants’ Home of Montreal, a member of the management committee of the Industrial Rooms, and from 1888 a life governor of the Montreal Maternity Hospital. She served on the board of management of the Protestant Hospital for the Insane in Verdun at its opening in 1890. She also made a contribution to the cause of higher education for women as the second president of the Montreal Ladies’ Educational Association, from 1873 to 1875, taking over the post from her sister-in-law Anne Molson. She used her wealth with intelligence and discretion, helping the organizations which she felt most needed it, e.g., the Montreal Ladies’ Benevolent Society, a large charity for children of single-parent families.

In 1873, she married John Henry Robinson "Jackey" Molson (1826–1897). She died on August 12, 1910, in Montreal, Quebec.