The fonds consists of books, letters, documents, drafts, publications, photographs, and several artifacts collected by W. W. Francis and Marian Francis Kelen over the course of their lifetimes. Many books and documents relate to Sir William Osler and the Osler family including several personal letters, the Deed of Trust documents regarding the Bibliotheca Osleriana, drafts of Osler's works, and a wooden travelling trunk that belonged to Edward Revere Osler. The fonds also includes original poetry written by Marian Osborne, W. W. Francis, and Marian Francis Kelen.

The fonds consists primarily of Logan's scientific work. A small percentage relates to the affairs of his family and to memorials to Logan after his death. The great majority of the papers consists of scientific correspondence from about 1820 to 1874, but mostly for the years following his appointment to the Survey in 1842. The letters deal with the collection, exchange and description of geological specimens, expeditions under the aegis of the survey, problems of research and scientific interpretation, scientific meetings, and visits by scientists. The number of correspondents, both individuals and learned societies, is very large, but the most substantial bodies of letters are from J.W. Dawson, geologist and Principal of McGill University, James Hall, paleontologist of the New York Geological Survey, Alexander Murray, Logan's chief assistant, and James Lowe of Grenville, Québec, who supplied Logan with specimens and appears to have been casually employed by him on surveying jobs and field trips. Other correspondents include Sanford Fleming, E.D. Ashe of the Québec Observatory, Thomas Sterry Hunt, and R.I. Murchison of the Geographical Society of Great Britain. Some letters pertain to political or social affairs, but usually in close connection with the scientific work of Logan or the Survey. These files contain copies of some of Logan's outgoing letters, as well as some letters addressed to other individuals, generally his assistants. Other scientific papers consist of field trip records (a journal kept during an expedition in 1845, a weather table kept on Lake Superior in the winter of 1846-1847, work records and astronomical readings for surveying projects, notes on mineral deposits, and lists of specimens), manuscripts of three scientific papers, as well as "Observations on the proposed Geological Survey", and manuscript and printed maps and geological schemata, including some by Logan of the Bay of Fundy, Labrador, and Hamilton, Ontario regions. Manuscript catalogues of specimens were prepared by Logan for the Paris Exhibitions of 1855 and 1867. Official reports include Logan's annual reports for 1842-1844, an overview of the work of the Geological Survey, 1866, two reports by Logan on prospects for mining on the north shore of Lake Superior, 1846, 1847, and one on mineral deposits around Rivière-du-Loup, 1853, as well as Logan's copy of his proposed Geological Survey Bill, 1844, and some copies of reports on mining and cartography prepared by others. Logan's financial records include expense accounts for Geological Survey expeditions, as well as other professional expenditures, such as books. His private and family life is reflected by a very brief diary of an Atlantic crossing in 1856, letters to and from his brothers James and Henry, his father, his uncle Hart Logan, and Hart Logan's partner John Fleming, covering the years 1772-1856. There are also baptismal and burial certificates, and legal documents, particularly bills of sale pertaining to James Logan's farm. Memorials to Logan after his death include J.W. Dawson's correspondence concerning the Logan Memorial Fund and Collection, 1881, and a manuscript biography by Alexander Murray. There is a chronological and author/recipient index to these papers.

Additional materials received from McGill Library's Rare Books and Special Collections consist of correspondence, 1837-1871; notices of admission to scientific and historical societies, 1842-1867; a history of the geological survey 1850; a report on mining locations addressed to B. Papineau, 1847; and correspondence with Robert Bell, 1861-1874.

Letter from George Washington, thanking Cochrane for assistance with some hounds sent by the Marquis de la Fayette and declining to promote him (or his client) to the office of Continental Treasurer.

Frobisher's papers comprise a letterbook of the North-West Co. containing copies of letters written by Frobisher from April 1787 to October 1788, two original letters to Simon McTavish, 1796, and one from him, 1787, business and legal documents, largely concerning the estate of James McGill, 1810-1834, and a diary, 1806-1810, mostly a record of where he dined.

McDonald's correspondence, 1791-1860, mostly concerns business and property matters, but also includes personal correspondence. There are statements of account with McTavish, Frobisher & Co., 1799; with McTavish, Fraser & Co., 1803-1804; with McTavish, McGillivray & Co., 1808-1809. There are two volumes of autobiographical notes assembled in 1859 and covering the period 1791-1816.

There is a second copy of the autobiography, probably transcribed in the late 19th century. Written on the front fly leaf is the name: A.E. MacDonald. It has 63 leaves, and there are minor textual variants.

There is business correspondence, 1792-1800, with letters from among others Alexander Mackenzie, Joseph Frobisher, Alexander Henry, Simon Fraser and Roderick Mackenzie. There are also minutes and resolutions of the Executors of McTavish in a bound volume; and a contemporary copy of the minutes of the executors of his will, 1805.

The Sir William Osler Collection, distinct from the Bibliotheca, is an extensive archival holding of Osler's correspondence (including eighteen hundred original letters), daybooks, accounts, engagement books, legal documents, book invoices, membership certificates, notebooks, lectures, addresses, newspaper clippings, photographs, books with manuscript additions, and miscellaneous loose items formerly inserted into individual books in his library. The collection also contains various family papers, including correspondence of Lady Grace Revere Osler and Edward Revere Osler.

This collection consists of contemporary copies of letters written by T. Blackwood from Michilimackinac to James and Andrew McGill & Co., to Ch. Chaboillez, and to T. and J. McGregor.

Typed copies of the official and private correspondence, 1814-1821, held in the McCord Museum in the William MacKay Papers. They consist mainly consist of military records such as commissions, 1813-1814, correspondence between members of the British Indian Department, including Lt. Col. Robert McDouall and his description of the siege of Prairie du Chien, with reference to the Omaeqnomenew (Menominee), Hocak (Winnebago), and Meskwaki (Fox) warriors who fought alongside British forces, as well as to the Potawatomi leader Main Poc (referred to as Marpock), 1814-1815 and copies of correspondence of Capt. Thomas Anderson with Lt Col. Robert McDouall on military actions, supplies and Indian relations, 1814-1815. There is also a newspaper clipping about Alexander MacKay and the partnership agreement admitting William MacKay and David Mackenzie into the North West Company in 1796.

The bulk of Girdwood's papers concern his work in forensic medicine. Other materials cover his research in photography, and his general medical and scientific interests. Girdwood's career as medical-legal consultant is documented by 24 cm of his notes and reports, together with some correspondence, on four poisoning trials: People vs Emma Davis (Malone, N.Y., 1881), Queen vs Provencher and Boisclair (Sorel, 1867), Queen vs Joseph Ruel (St. Hyacinthe, 1868), and Queen vs David Prevost and Damase Brunet (L'Orignal, 1881). There are also coroner's autopsy reports and notes for four cases; Girdwood's memoires of ten cases on which he served as consultant; Rogers and Girdwood's submission to the Home Office, London, on the strychnine test, together with letters to Lancet and the Times on the same subject; and notes on the counterfeiting of stamps (1893). His interest in medical photography is reflected in lists of X-rays taken by him (1898-1899) and reprints of three articles. His general scientific and medical activities are represented by a scrapbook of newsclippings on cholera (1854), a lecture on gold presented to the Natural History Society of Montréal (n.d.), essays on strychnine (1864) and water filtration (1869), a review of a textbook in physiology (1864) and some reprints, including convocation addresses to the Medical Faculty. Finally, there is a manuscript copy of an address to the graduating class of Applied Science in 1881 and a small scrapbook of printed articles by Girdwood's father, G.F. Girdwood, M.D.