Fonds shows, partially, Francis John Shepherd's activities as a medical student, an author and a dean. It contains his manuscript student notebook on Materia Medica, an admission card to the University Lying-In Hospital and correspondence with among others John George Adami who writes about his leave at Chicago and Harvey Cushing about Sir William Osler.

Fonds contains G.D. Gibb's manuscript medical case books. The fonds includes six volumes originally numbered 3, 7, 8, 9, 11, 12, each of them with an index and Gibb's bookplate.

Fonds contains correspondence mostly between George Dock and Sir William Osler but also with Lady Osler, W.W. Francis and Archibald Malloch, from 1891 to 1919. The fonds includes 106 letters, originals and carbon copies.

Fonds documents the friendship between Tooke and William Boyman Howell through the letters from William Boyman Howell, retired in England, to Frederick Thomas Tooke in Montreal, during the Second World War, from 1941 to 1947.

Fonds shows F.W. Harvey's medical activities and his interest in physical training. The fonds contains 2 day books, an obstetric record, a ledger and a scrapbook.

The fonds contains the research work of Dr. Simpson in preparation of his biography of Austin Flint.

The fonds documents the Osler Society's activities. The fonds contains lectures, dinner menus, list of speakers, newsletters, papers, posters and tape recordings.

The fonds contains correspondence concerning a dinner in honour of Sir William Osler at the University Club, New York, organized by Beverly Chew, M. Taylor Pyne, Edward G. Kennedy, William Augustus White, Frederick R. Halsey and Ernest Dressel North in 1913. The fonds includes 74 original letters. E.D. North managed the correspondence for the event, which included numerous bibliophiles.

A partial inventory of this collection reveals that it is largely composed of the scattered personal papers of the members of the Worthington Family, ca. 1833-1944, especially those of Edward Dagge Worthington and Arthur Norreys Worthington. The fonds also includes a few items pertaining to Edward Bruen Worthington and Asheton N. Worthington. It includes personal, business and professional correspondence; certificates, diplomas, tests, maps, sketchbooks, loose ledger sheets, testimonials, photographs and newspaper clippings. The greater part of the collection consists of the papers of Edward Dagge Worthington including correspondence related to his business affairs, medical career and family matters (1840-1883); medical certificates and diplomas, (1840-1847); two sketchbooks, (1840?); with caricatures of John Goodsir, Alexander Munro, Robert Knox and William Robertson; testimonials (1865, 1867); a resume of his education covering 1833-1843; newspaper clippings and photographs. The papers of Arthur Norreys Worthington are primarily correspondence describing his military activities in South Africa, 1900.