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The fonds contains original and typescript letters, manuscript notes, newspaper clippings, journal extracts, reminiscences and more, assembled by Harvey Cushing chiefly between 1920 and 1924 during the course of his research for the biography of William Osler. For the biography, Cushing collected and retyped over 7500 pieces of Osler's correspondence, among which are some original letters.

The fonds is separated into three series: Manuscripts, Working Notes and Osler's Correspondence. It also contains photographs, annual reports, publications, clippings, one watercolor painting, one postcard. Osler's correspondence is further arranged in three subseries based chronologically.

The fonds consists of Dr. Campbell's partially edited and unfinished autobiography, which he began writing in the 1960s and continued until the time of his death in 1970. The work covers the period from, approximately, 1831 to 1932. Additionally, the fonds includes the medal Dr. Campbell received for serving as Past President of the Montreal Medico Chirurgical Society, 1952-53.

Fonds consists of the personal and professional papers of Louis and Irene Kon including extensive correspondence between the Kon family. Included are materials relating to the founding of the Norman Bethune Foundation and Bethune memorials; the making of Ted Allan's movie, "Making of a Hero", including the conflict with Syd Gordon regarding creative differences; a manuscript draft and notes on Larry Stephenson's manuscript 'Two Petrals.'

The fonds contains materials that Dr. M. Entin collected for his biography of Dr. Archibald. Mainly include articles relate to tuberculosis, pancreatitis, wound healing, history of surgery, and scientific writing. It also includes letters from Edward Archibald to Mrs. Archibald, letters to Archibald from William Osler and Sir Henry Gray, addenda of Archibald's world journey in 1936, and articles by Archibald.

Some draft chapters of the biography of Dr. Archibald and research data for 100th Anniversary of Royal Victoria Hospital can also be found in the fonds.

The collection consists of documents pertaining to Dr. H. S. Birkett's medical activities, including 117 bound volumes of patient records (1889-1942), medical notebooks (1893-1896), bound RVH reports (1894-1938), RVH charts (1901-1920) and registers (1899-1917). There are also various letters addressed to Mr. and Mrs. Birkett, a manuscript, newspaper clippings, various degrees and medical association certificates, as well as photographs of H. S. Birkett's personal life and professional life at McGill and elsewhere. The collection also includes various artifacts collected by H. S. B, including military and medical memorabilia collected by H. S. Birkett.

The fonds documents William B. Howell's poetry. The fonds contains a bound typescript of poems with two drawings by W.W. Francis.

The fonds contains the manuscript of his book William Osler : A Life in Medicine.

Fonds documents Dr. Alton Goldbloom's professional activities, mainly his writings on pediatrics. The fonds contains diplomas, notice of appointment, correspondence, notes, reprints, manuscripts of I'm on Your Side, Small Patients, and revised text of Le soin de l'enfant.

Fonds documents Dr. H.E. MacDermot's medical-historical activities. The fonds contains newspaper clippings, manuscript notes, photographs, lectures notes, and a draft of The MGH, the Years of Change.

The fonds documents mainly Babkin's professional interests in physiology, especially glandular secretions and the nervous system. The fonds contains correspondence; lecture notes; citations; research notes and papers, including manuscripts sent to him by his colleagues; reprints of scientific articles mainly in Russian; and material used in the preparation of the biography of Ivan Pavlov. The latter contains correspondence with Ivan Petrovich Pavlov and members of his family, 1923-1948; photographs and portraits; and an unabridged typescript copy of Parts 1-3 of Pavlov: a Biography, with manuscript corrections, 1943-1946.