The Penfield fonds consists of over eighty metres of Penfield's personal and professional records dating from his childhood up until his death in 1976, including during his career at the Montreal Neurological Institute. The materials in the fonds include photographs, correspondence, manuscripts and drafts of publications and speeches, research notes, glass slides, bound reports, films, and academic gowns.

The fond consists of artifacts, bound volumes, photographs, and records from the Montreal Medico-Chirurgical Society. Included are correspondence, minute books, reports, monthly bulletins, a register of members, memorabilia, and albums of clippings and photographs.

Files 46-62 in particular include a significant amount of minutes, newsletters, and event information. Correspondence, reports, publications, press clippings and photographs comprise a smaller portion of the files. Secretarial and annual reports, activities, and minutes from the Rheumatology section are included. The society's gavel is part of this fonds.

The fonds consists of books, letters, documents, drafts, publications, photographs, and several artifacts collected by W. W. Francis and Marian Francis Kelen over the course of their lifetimes. Many books and documents relate to Sir William Osler and the Osler family including several personal letters, the Deed of Trust documents regarding the Bibliotheca Osleriana, drafts of Osler's works, and a wooden travelling trunk that belonged to Edward Revere Osler. The fonds also includes original poetry written by Marian Osborne, W. W. Francis, and Marian Francis Kelen.

Fonds shows Alphonse Allard’s activities as a medical student at McGill University from 1863 to 1865. It contains seven admission cards autographed by the teachers and also a certificate from the College of Physicians and Surgeons of Lower Canada

Collection consists chiefly of photographs of Harold N. Segall, Assistant Professor of Medicine at McGill (1949-1960) and President of the Canadian Heart Foundation, Montreal Cardiac Society, and the Quebec Heart Foundation, as well as his parents, brother Jerry Segall, friends, and colleagues. Photographs depict Segall's childhood and early career. There are also some photographs and textual records relating to Segall's association with professional societies and Montreal hospitals, namely the Canadian Heart Association, Montreal General Hospital, and the Jewish General Hospital.

The fonds consists of six bound manuscripts of notes on medicine written in 1871 and 1872 by Joseph Odilon Lauriault while he was a medical student at Laval University. Includes notes on lectures given by Dr. Simard, Dr. Landry, Dr. Jackson, and Dr. Larue, on topics including surgery, birth, pathology, and gynecology.

The fonds contains correspondence related to the Osler Library and its holdings with people such as Maude Abbott, Edward Archibald, William B. Bean, Edward Horton Bensley, Archibald Malloch, Casey Wood, as well as John Farquhar Fulton, Keeper of the Medical History Collections at Yale University's library; the fonds also contains a typescript of talks by W.W. Francis (titled "Showman's Patter") about books and other items held in the Osler Library.

Fonds contains five notebook kept by medical student S. J. Bennett while studying at McGill University's Faculty of Medicine. Each notebook is devoted to a subject of study, including one notebook each labelled "Medicine", "Bacteriology" and "Obstetrics" and two notebooks labelled "Pathology." The notes inside are dated between 1907 and 1908. The notes are organized in some cases by instructor and in some cases according to medical conditions.

The collection consists of documents pertaining to Dr. H. S. Birkett's medical activities, including 117 bound volumes of patient records (1889-1942), medical notebooks (1893-1896), bound RVH reports (1894-1938), RVH charts (1901-1920) and registers (1899-1917). There are also various letters addressed to Mr. and Mrs. Birkett, a manuscript, newspaper clippings, various degrees and medical association certificates, as well as photographs of H. S. Birkett's personal life and professional life at McGill and elsewhere. The collection also includes various artifacts collected by H. S. B, including military and medical memorabilia collected by H. S. Birkett.