Sub-series consists of 32 cassettes, recorded between 1955 and the end of the 1970s, created to accompany the Cree language course developed by C. Douglas Ellis. First published in 1962, the course was revised and reissued in 3 volumes in 2000. Tapes correspond to lessons in Spoken Cree: Level I and Spoken Cree: Level II. Instruction is in the N-Dialect, or Swampy Cree, spoken on the west coast of James Bay. Guidelines for applying lessons to the L-Dialect are given in audio.

Sub-series consists of lessons recorded on 35 cassettes with spine label Cree A3 and 29 cassettes labeled Cree A5 ; These correspond to the textbooks "Cours de Cris: Première Degré," and "Cours de Cris: Deuxième Degré." Both texts are authored by Louis-Philippe Vaillancourt, and published by Les Presses de l’Université du Quebéc.
The focus of instruction is Cree as spoken on the east coast of James Bay, and lessons are presented with the participation of residents from Wemindji and Eastmain. Lessons on the A3 cassettes center on building a basic vocabulary through listening and repetition, lessons on the A5 cassettes concentrate on transitive and intransitive verbs. The sub-series also contains one folder of plastic sleeves holding 25 compact discs. Discs are labeled to correspond to audio cassettes in the A3 series, likely from an earlier format transfer project.

Sub-subseries consists of Dr. Penfield's collection of glass lantern research slides.

Sub-subseries consists of visual and some textual information concerning particular neurological cases. This material was sent to Dr. Penfield by other neurologists. (E/VS = Events / Visual Sent)

Sub-subserise consists of pictorial records of events at the Montreal Neurological Institute. (E/VN = Events / Visual Neuro.)

Sub-subseries consists of portraits and portrait snaps of Dr. Penfield and his family, in vertical files. (E/V-WGP = Events / Visual-Personal)

Sub-subseries consists of published photo stories about the Montreal Neurological Institute. (E/PV = Events / Published Visual)

Sub-subseries consists of published material concerning McGill University and/or Dr. Penfield. (E/PS = Events / Published Standard)

Sub-subseries consists of published accounts regarding the Montreal Neurological Institute. (E/PN = Events / Published Neuro.)

Sub-subseries consists of published accounts regarding McGill University. (E/PM = Events / Published McGill)