Simpson's papers contain personal records, student materials, and lectures delivered by him. The personal materials consist of a file of letters of appointment to the Indian Commission, Bishop's University, the Montreal General Hospital, and various insurance companies, as well as testimonial letters from Robert Craik and G.W. Campbell. Simpson's outgoing letterbook contains copies of correspondence from his Indian Commission period concerning salary, accomodation, medical supplies and other aspects of his work. Included are two diaries. One describes his trip to Europe, 1857-1858, giving quite full descriptions of hospitals and clinics, as well as sight-seeing, in Paris and the British Isles. The second diary, from 1865 to 1903 is less detailed. Finally, there is a file of personal documents, e.g. his birth certificate and instructions concerning his funeral, 1897. Apart from lecture attendance cards, materials from Simpson's student days consist of a notebook for a number of medical courses, 1853-1854. Simpson's teaching career is documented by a lecture on phlebitis, ten lectures on veneral disease, 1878, five on syphilis, 1881 and a convocation address, 1884.