Fonds documents J.B. Johnston's professional activities from 1839 to 1859. It also includes his medical thesis De delirio tremente, Edinburgh, 1833. The fonds contains a logbook with notes, summaries of readings, reports of unusual medical cases and obstetrical list, and his medical thesis.

Fonds contains G.D. Gibb's manuscript medical case books. The fonds includes six volumes originally numbered 3, 7, 8, 9, 11, 12, each of them with an index and Gibb's bookplate.

The collection consists of documents pertaining to Dr. H. S. Birkett's medical activities, including 117 bound volumes of patient records (1889-1942), medical notebooks (1893-1896), bound RVH reports (1894-1938), RVH charts (1901-1920) and registers (1899-1917). There are also various letters addressed to Mr. and Mrs. Birkett, a manuscript, newspaper clippings, various degrees and medical association certificates, as well as photographs of H. S. Birkett's personal life and professional life at McGill and elsewhere. The collection also includes various artifacts collected by H. S. B, including military and medical memorabilia collected by H. S. Birkett.

Fonds contains notes taken by Thomas McCrae between 1897 and 1904 at William Osler's clinics at the Johns Hopkins Hospital, Baltimore.