The fonds consists of books, letters, documents, drafts, publications, photographs, and several artifacts collected by W. W. Francis and Marian Francis Kelen over the course of their lifetimes. Many books and documents relate to Sir William Osler and the Osler family including several personal letters, the Deed of Trust documents regarding the Bibliotheca Osleriana, drafts of Osler's works, and a wooden travelling trunk that belonged to Edward Revere Osler. The fonds also includes original poetry written by Marian Osborne, W. W. Francis, and Marian Francis Kelen.

Fonds primarily documents Armstrong’s social life. They consist overwhelmingly of correspondence for the period 1909-1933. Letters from his professional colleagues, such as Sir William Osler, F.J. Shepard, Edward Archibald, William J. Mayo and others in the Mayo Clinic, are concerned largely with personal greetings, association memberships, or Medical Faculty business, particularly honorary degrees. Armstrong's non-medical correspondents include Lord Beaverbrook, Lord Atholstan, Sir Hugh Allan, Arthur Meighen, George Foster and Herbert Symonds. Topics include politics, Armstrong's war work and honours, some medicals matters, and personal news. Appended to this main series are obituaries and letters of sympathy to Armstrong's widow (1933), six photographs, including one of Armstrong in an operating room, and admission cards and diplomas from Armstrong's student years.

The fonds contains original and typescript letters, manuscript notes, newspaper clippings, journal extracts, reminiscences and more, assembled by Harvey Cushing chiefly between 1920 and 1924 during the course of his research for the biography of William Osler. For the biography, Cushing collected and retyped over 7500 pieces of Osler's correspondence, among which are some original letters.

The fonds is separated into three series: Manuscripts, Working Notes and Osler's Correspondence. It also contains photographs, annual reports, publications, clippings, one watercolor painting, one postcard. Osler's correspondence is further arranged in three subseries based chronologically.

Fonds contains lecture notes taken by Robert Struthers at McGill Medical College in 1881-1882, including notes on Pathology, Surgery and Ophthalmology. Lecturers include Robert Palmer Howard, Sir Thomas Roddick and Sir William Osler. There is also a case report by Struthers. The fonds includes two notebooks and a case report.

Fonds documents the friendship between Mrs. Alice Russel and Dr. Abraham Flexner. It also includes documents collected by Mrs. Russel on Sir William Osler and Maude Abbott. The fonds contains correspondence and newspaper clippings.

The fonds contains materials that Dr. M. Entin collected for his biography of Dr. Archibald. Mainly include articles relate to tuberculosis, pancreatitis, wound healing, history of surgery, and scientific writing. It also includes letters from Edward Archibald to Mrs. Archibald, letters to Archibald from William Osler and Sir Henry Gray, addenda of Archibald's world journey in 1936, and articles by Archibald.

Some draft chapters of the biography of Dr. Archibald and research data for 100th Anniversary of Royal Victoria Hospital can also be found in the fonds.

Fonds shows Dr. Philip Franklin's relations and activities with Sir William Osler regarding the Post-Graduate Scheme in England and the American Hospital in England during WWI. The fonds contains letters, telegrams and an agenda and printed material regarding a meeting about the American Hospital.

The fonds contains the manuscript of his book William Osler : A Life in Medicine.

Fonds documents Dr. F.C. MacIntosh's teaching and research activities at McGill. The fonds contains correspondence, newspaper clippings, reprints of publications, photographs, documents related to the International Union for Physiological Sciences, lectures, and student reports. The fonds also contains a dossier on Professor George Ralph Mines (1886-1914) assembled by Dr. MacIntosh from 1982-1986. The dossier includes publications, photographs, obituaries, and autopsy information of G.R. Mines, as well as correspondence regarding his death and a copy of "The short brilliant career and strange death of G.R. Mines," written by MacIntosh in 1985.