The bulk of the Hunt papers consists of scientific correspondence, with a fairly large component of notes on scientific subjects. Most of the material dates from after Hunt's departure for the United States. With the exception of a letter of appointment to the Geological Survey of Vermont in 1845, all Hunt's correspondence (incoming, with copies of some outgoing) dates from the period 1863-1891, with the majority of items from the 1880s. There are a few letters of a social or personal nature, but most concern scientific matters: geological and chemical research problems, exchange of specimens, Hunt's theories and the controversies they stirred, his publications, negotiations for patents on some of his discoveries, the business of various scientific societies, and in particular the organization of the Geological Congress. Amongst his correspondents were James D. Dana (with whom he engaged in a heated quarrel over scientific theory), James Hall, Persifor Frazer, J.W. Dawson, and various members of the Geological Survey of Canada, such as G.M. Dawson, Robert Bell, Henry Y. Hind, and George Iles. Hunt's scientific notes mostly deal with special topics in chemistry, geology, mineralogy, railways, coal products and the controversy with Dana. There are also reading notes for geological texts, lecture notes for courses in geology, 1876, and chemistry, and indexes, apparently for Hunt's books. A manuscript on "Benjamin Franklin's Autobiography: an episode in its history", notes for a lecture on "People I have met", and sketches of family history represent Hunt's wider interests. There are also clippings of reviews of books and lectures by Hunt, biographical notices, reports on scientific themes and institutions, and news of the Geological Survey.

Fonds consists of autographed signed letter from Workman to John Auld of Montreal on Workman’s engraved stationery (Matthews lithographer), 25 November 1852.

Fonds primarily documents Armstrong’s social life. They consist overwhelmingly of correspondence for the period 1909-1933. Letters from his professional colleagues, such as Sir William Osler, F.J. Shepard, Edward Archibald, William J. Mayo and others in the Mayo Clinic, are concerned largely with personal greetings, association memberships, or Medical Faculty business, particularly honorary degrees. Armstrong's non-medical correspondents include Lord Beaverbrook, Lord Atholstan, Sir Hugh Allan, Arthur Meighen, George Foster and Herbert Symonds. Topics include politics, Armstrong's war work and honours, some medicals matters, and personal news. Appended to this main series are obituaries and letters of sympathy to Armstrong's widow (1933), six photographs, including one of Armstrong in an operating room, and admission cards and diplomas from Armstrong's student years.

Correspondence, accounts, journals maps, etc., documenting Bissett’s career with the Hudson’s Bay Company. The Photostats (in C.1 and C.2) include Bissett’s journal and accounts at the Red River, 1854-1855, and a journal “Lachine to the Sandwich Islands” 1858-1859. There are also journals for 1859 and 1867. The original documents (in C.3) include correspondence with the Hudson’s Bay Company, 1858-1875, and accounts, 1860-1873. There are Bissett’s commissions as Chief Trader (1858) and as Chief Factor (1872), and a list of Chief Traders and Factors, 1855-1879. There are also some plans / maps, sketches, and photographs including a sketch of the Hudson’s Bay Post at Honolulu, ca. 1860.

Gould's papers fall into two series. Family correspondence covers the years 1856 to 1860, when Joseph and his brother Charles were travelling in Europe, and consists of letters home from both young men, and their parents' replies. Manuscript music comprises two volumes of church anthems, with some organ music; some are original compositions by Gould and Samuel Warren. Related to this is Gould's brief manuscript account of the origin of the Mendelssohn Choir. Some family photographs are also included.

The fonds contains original and typescript letters, manuscript notes, newspaper clippings, journal extracts, reminiscences and more, assembled by Harvey Cushing chiefly between 1920 and 1924 during the course of his research for the biography of William Osler. For the biography, Cushing collected and retyped over 7500 pieces of Osler's correspondence, among which are some original letters.

The fonds is separated into three series: Manuscripts, Working Notes and Osler's Correspondence. It also contains photographs, annual reports, publications, clippings, one watercolor painting, one postcard. Osler's correspondence is further arranged in three subseries based chronologically.

Letters and papers relating to employment with the Hudson’s Bay Company. These include letters of appointment, official announcements, lists of officers of the Hudson’s Bay Company, and an inventory the posts and officers in the Albany River district.

The Ross family fonds consists primarily of records related to the student achievements of the Ross children and includes student notebooks, news clippings, convocation programmes, certificates, and memorabilia of the Red and White Revue such as songs, photographs and original songs. Edward Russell Paterson’s student notebooks in geology, petrography and English literature are included.

In addition, there are two diaries of William Stieven Paterson’s from his travels through Civil War battlefields in the southern USA and a trip to Cuba; 8 photograph albums depicting the Paterson side of the family; 3 scrapbooks of magazine stories for children, poems and household hints; and correspondence between Dorothy Jean Ross and the McGill University Archives.

The fonds contains professional and private correspondence from Emma Albani, the first Canadian-born singer of international fame, to Parisian publisher Henri Heugel.