The collection contains business correspondence, including letters to William Grant and Grant, Campion & Co. from Brickwood, Pattle, & Co., 1792-1793, and letters from Brickwood & Daniell, John Blackwood, and McTavish, Fraser and Co., 1799-1800. There is also a bound letter book for Grant and Laframboise, Montreal, 1800-1801 with additional loose leaves of letter copies dating between 1798 and 1800.

Correspondence (5), including a draught of a letter (unaddressed) about the Jesuit Estates and correspondence with Charles Antoine Taschereau (at Paris) and Grant to of Blairfindy (at Versailles), concerning acquaintances and relatives in France.

The fonds is composed of correspondence; course material; drafts of articles, books and other works; financial and judicial records, such as benefits statements or contracts; material written for public addresses, such as speeches or notes; photographs of Mr Watson; and a short section focusing its attention on the various appointments he had. This fonds is particularly interesting for the shear amount of course material that one can find here. Indeed, it composes a good third of the entire volume of this fonds and spans 20 courses over 40 years of teaching.

While attempting to give a complete look at William Watson’s life, the fonds is distributed into the following 5 series:
A. Biographical records
B. Professional records
C. Distinctions
D. Correspondence
E. Graphical material

The fonds shows W. G. Henry's activities as a medical student at the Toronto School of Medicine and then at the Faculty of Medicine, McGill University, from 1878-1883. The material consists of 18 printed cards made out in writing to W. G. Henry: 6 from the Toronto School of Medicine for the sessions 1878-79 and 1879-80 (1 proof of registration/lecture programme card, 5 admission tickets); 6 from the University of McGill College or Faculty of Medicine, 1880-1882 (4 admission tickets, a certification card, an initialed dissection examination card); 5 certification cards from the Montreal General Hospital, 1881-1883; an admission tickets for the "University Dispensary" (undated).

This collection consists of incoming correspondence concerning some of Gardner's patients, 1898-1900.

An address on "The primitive use of poisons" read before the Osler Society in 1921.

Fonds contains the admission cards of William Forrest for the Montreal Medical Institution Library, the Montreal General Hospital and the lecture of Anatomia Physiologia et Chirurgica of John Stephenson, in 1824-1825. The fonds includes three admission cards.