The collection consists of documents pertaining to Dr. H. S. Birkett's medical activities, including 117 bound volumes of patient records (1889-1942), medical notebooks (1893-1896), bound RVH reports (1894-1938), RVH charts (1901-1920) and registers (1899-1917). There are also various letters addressed to Mr. and Mrs. Birkett, a manuscript, newspaper clippings, various degrees and medical association certificates, as well as photographs of H. S. Birkett's personal life and professional life at McGill and elsewhere. The collection also includes various artifacts collected by H. S. B, including military and medical memorabilia collected by H. S. Birkett.
Macdonell's papers comprise a journal for 1793-1795, which L.R. Masson entitled "Assinoboines-Rivière Qu'appelle", and an account of the Red River, approximately 1797.
Approximately half this material consists of letters, covering the years 1823-1837, from Andrew William Cochran, 1792-1849, civil secretary to the governors of Lower Canada from 1812 onwards, and a member of the Executive Council from 1827 to 1841. The remainder comprises a number of accounts of travels and exploration by North West Company employees, probably collected by McKenzie for his history. Included are Charles McKenzie's expeditions amongst the Otoe Missouria Tribe.; Edward Umfreville's journal of a canoe trip from Lake Superior to Portage de l'Isle 1784; accounts of the Alaskan Athabaskans, 1795 and 1805, George Keith's memoirs of the McKenzie River Department, 1807-1817; and George Henry Monk's of the Department of Fond du Lac or Mississippi, 1807; John McDonnell's account of the Red River, ca 1787; and John Johnston's of Lake Superior and a letter on the Indigenous communities of the northwest from Eneas McDonnell. Also included are letters written to McKenzie from Forks on the Mackenzie River by William Ferdinand Wentzel, 1807-1824.
Fonds contains "The journal of an English lady; or letters descriptive of the continent during the years 1829 and 1830" to which have been added water-colour illustrations by the author.