The fonds illustrates Charles Lewis's work in pharmacy and includes a collection of his father's records, also named Charles Lewis. It contains books, drug formulae books, manuscripts, diplomas, licenses, certificates, patent documents, catalogues, testimonials, notes, correspondence, legal documents, financial documents, business documents, and obituaries.

Collection consists of 36 autograph letters written to James Cameron and his son Archie. The correspondence includes letters by friends, associates, and members of the Cameron family in Toronto, Lake Beauport, Scotland, England, Hull, and Montreal. Subjects include family news, freemasonry, business (regarding deed of sales), factory work in Toronto, curling, and an April Fools' Day letter. With three extant envelopes.