A partial inventory of this collection reveals that it is largely composed of the scattered personal papers of the members of the Worthington Family, ca. 1833-1944, especially those of Edward Dagge Worthington and Arthur Norreys Worthington. The fonds also includes a few items pertaining to Edward Bruen Worthington and Asheton N. Worthington. It includes personal, business and professional correspondence; certificates, diplomas, tests, maps, sketchbooks, loose ledger sheets, testimonials, photographs and newspaper clippings. The greater part of the collection consists of the papers of Edward Dagge Worthington including correspondence related to his business affairs, medical career and family matters (1840-1883); medical certificates and diplomas, (1840-1847); two sketchbooks, (1840?); with caricatures of John Goodsir, Alexander Munro, Robert Knox and William Robertson; testimonials (1865, 1867); a resume of his education covering 1833-1843; newspaper clippings and photographs. The papers of Arthur Norreys Worthington are primarily correspondence describing his military activities in South Africa, 1900.

The fonds contains two sketchbooks of coloured sketches and shows William Arthur Johnson's activities in natural sciences and microscope work.

The collection consists of six of Walter Crane’s sketchbooks. Two of the sketchbooks date to the summer of 1864, and the remaining four date to the summers of 1897, 1901, 1903, and 1905. The collection’s dates offer a contrast between Crane’s early and later career as an artist. The contents feature his preliminary designs, pictorial observations of the world, and textual notes.

Crane’s sketchbooks are filled with landscapes and towns and building interiors and exteriors from Crane’s life in England and travels to Ireland. Aligned with Crane’s commissioned and published works, the sketchbooks include sketches for his book designs, a heraldic eagle, and plans for a panel painting or frieze. Flora, fauna, men, women, children, Greco-Roman figures and architectural details make up the wide range of subjects covered in the sketchbooks.

The drawings range from Crane’s rough ideas expressed in his preliminary sketches and line drawings to tonal drawings and studies of individuals, landscapes, and flowers. The drawing techniques play with perspective, topography, bodily gesture, facial expression, tone, line, outline, form, and colour.

Crane’s notations appear throughout the sketchbooks, including on the sketches themselves and on their facing pages. He also hand-wrote inspirational excerpts from poems and essays which includes quotes from Charles Kingsley and John Ruskin works.

Between blank and torn pages, the medium for the textual and visual content shifts between pen and pencil on paper. Several landscapes are full-page watercolours on paper.

Fonds reflects Shirley Goodall's work as a medical illustrator on the service of various McGill physicians. The fonds consists chiefly of sketches in pencil on paper, medical illustrations mounted on board. Also includes reprints of journal articles where many of her illustrations were published.