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Lanceford Bramblet Wilkes was born on March 27, 1824, in Maury County, Tennessee.
He was a preacher, educator, debater, writer, and leader in the American restoration movement. His family moved to Missouri when he was five. In 1849, he entered Bethany College, West Virginia, but soon returned to Missouri to attend State University. He participated in a series of discussions about the restoration movement. Wilkes taught and was appointed president of Christian College in Missouri in 1856. He preached in Hannibal, Missouri and Springfield, Illinois. In the 1880s, due to family health issues, Wilkes moved to California. He published the book "Moral Evil: Its Nature and Origin" (1892).
In 1854, he married Rebecca K. Bryan (1836–1888). He died on May 1, 1901, in Stockton, California.