Papers consist of personal correspondence, including substantial family correspondence, diaries, journals, engagement books, ledgers, menus, manuscript poems, galley proofs, lecture notes, scrapbooks, and photographs. It includes correspondence, 1874-1935; a diary of Drummond's trip to Great Britain, 1902; dinner menus, 1902-1903; engagement books, 1902-1906; galley proofs, 1905-1911; Journal of Impressions kept at Savanna la Mar, Jamaica, Windsor and Montreal, 1903-1911; lecture notes taken at McGill, 1878-1882; ledgers containing financial entries and patients' accounts during Drummond's practice in Knowlton and Montreal, 1885-1889; notebooks containing manuscripts poems, drafts and clippings, 1894-1909; scrapbooks related to literary topics, including clippings about Drummond's public readings, and book reviews, 1854-1907 and scrapbooks related to Drummond's dogs, 1890-1907. There are also some papers of Mrs. W.H. Drummond, including a typescript of her Life of W.H. Drummond; and diaries recording her trips to United States and Canada, 1892, 1903.

Fonds consists chiefly of a scrapbook created by Eleanor Wallis, née Eleanor Fisher, while a nurse at the Grenfell Mission in St. Anthony, Newfoundland, as well as diplomas and certificates for her and her husband, the physician Allan D. Wallis, and reprints of medical articles by Allan D. Wallis. The Grenfell album consists of photographs taken by Eleanor from 1933-1934 and printed items such as postcards, calendar pictures, and reproductions of photos made for sale by the Grenfell Mission. Photographs have handwritten captions with some personal annotations. One of the postcards shows a young nurse walking along a stretch of road leading to the village of St. Anthony's: this is Eleanor Fisher. Some later photocopies have been taped or laid in. Thirteen certificates and diplomas attest to Eleanor Fisher's training as a nurse (1929) and Allan D. Wallis's training as a physician (1925-1959), including Eleanor's Registered Nurse certificate, diploma from the Training School of Nurses of the Pennsylvania Hospital, and pediatrics nursing course certificate, and certificates attesting to Allan's residency training at the Pennsylvania Hospital, medical licence and diplomas, board certification in pathology, and a presidential certificate of appointment as an examining physician for the Pennsylvania Selective Service (this last is accompanied by a letter from the Governor of Pennsylvania). Two folders contain reprints of articles by Allan. D Wallis dating between 1941 and 1954. There are also 9 prints of photographs from the scrapbook, with captions on verso, accompanied by negatives. Lastly, there is one copy of a poem entitled "The Nurse" on oversized paper, the College of American Pathologists Code of Ethics, and one large group portrait photograph of hospital staff.

Fonds documents the friendship between Mrs. Alice Russel and Dr. Abraham Flexner. It also includes documents collected by Mrs. Russel on Sir William Osler and Maude Abbott. The fonds contains correspondence and newspaper clippings.

Fonds contains Dr. M.H.F. Friedman's personal papers and files relating to Dr. Boris P. Babkin and also correspondence with the editor of Babkin's biography of I.P. Pavlov.

Fonds contains the correspondence between Dr. Edmund Evan Simpson and the Osler Library Librarians, W.W. Francis and Cecile Desbarats, from 1942 to 1964. The fonds contains 21 letters, original and copies.

Fonds documents H.R. Clouston's medical activities and his association with McGill University. The fonds contains notes, reprints, photographs and newspapers clippings.

Fonds documents Dr. Antonio Cantero's professional activities, especially his cancer research. The fonds contains correspondence, notes, reports, printed matter, slides, photographs and films.

The fonds illustrates Dr. Sowden's work in the field of rehabilitation medicine and consists of slides, photographs, and articles.

The fonds contains Margaret Gillett's source materials and drafts for her book Dear Grace, a Romance of History. The source materials include original letters from William C. Little to Grace Ritchie written between 1889-1893.

The fonds contains chiefly of family correspondence between members of the Penfield and Chester families, as well as clippings and correspondence regarding Wilder Penfield's autobiography "No Man Alone" and correspondence regarding posthumous honours for Wilder Penfield. Family correspondence includes a 1917 letter from Helen Kermott (later Helen Kermott Penfield) accepting Wilder Penfield's marriage proposal. Much of the family correspondence is between Wilder and Helen Penfield and their daughter Priscilla and her husband William M. (Bill) Chester Jr., as well as Bill Chester's parents William (Sr.) and Alice Chester. There are incoming letters and many carbon copies of outgoing letters. A series of 1949 letters congratulates the young couple (Bill Chester and Priscilla Penfield) on their engagement. One letter is also between Wilder Penfield and George Chester. A few materials are related to posthumous honours for Wilder Penfield, such as the naming of a building after him at John Abbott College (letter to Wilder Penfield Jr.) and a 1982 speech given by Priscilla at the Penfield Children's Center (typescript copy). There is also correspondence between Bill Chester and William Feindel. One 1976 carbon copy of a letter (1976) details the period following the death of Priscilla's father, Wilder Penfield, while the couple was in Japan. Materials related to "No Man Alone" include clippings from journals and newspapers of reviews and book announcements, as well as two copies of the book jacket and some related correspondence.