The fonds primarily reflects Pappius’s activities as a researcher at the Montreal Neurological Institute-Hospital (MNI/H): both her experimental research as such and various support activities, including academic publication, coordination of research projects with colleagues, and acquiring funding. It also contains much information about her leadership of the Clinical Neurochemistry Laboratory. The fonds contains smaller amounts of documentation regarding her activities as a professor at McGill University, her administrative roles at the MNI/H, and her participation in professional organizations, which reflects the smaller place that those roles occupied in her professional life.

The period of time best documented in the fonds spans the early 1980s to Pappius’s retirement in 1995. Correspondence with colleagues, mostly though not exclusively work-related, contains relatively more material from Pappius’s early career; although, here too, most of the material dates from the 1980s and after.

The main document types in the fonds related to Pappius’s research activities are experiment worksheets and printed tabular research data. Many of the research-related files contain negatives of autoradiographies, with a smaller number of photographic prints. Correspondence can be found in many series besides series F (Correspondence), as much of Pappius’s work was collaborative in nature.

The fonds is divided into eight series: (A) Research, (B) Academic events, (C) Teaching, (D) Administrative activities, (E) Professional organizations, (F) Correspondence, (G) Personal collections, and (H) Visual documents.

Fonds shows H.R. Griffith's papers and records pertaining to his introduction of the homeopathic remedy curare into anesthesia. The fonds contains correspondence, case records, and reprints, as well as the minute book of the Montreal Homoeopathic Association, 1863-1968.

The fonds largely document Dr. Segall's professional activities as a cardiologist. It contains correspondence, notes, experimental notebooks, lecture notes, articles, speeches, patients' records, electrocardiograms, reprints and material pertaining to the Louis Gross Memorial Lectures, 1922-1979. Also included are several electrocardiograph machines, dictation devices, and audio recordings (reel-to-reel tapes, dictation disks, and cassette tapes). In addition, the fonds contain records of Dr. Segall's personal and family correspondence, financial transactions, and various other official and unofficial documents.

The fonds consists primarily of letters written during World War I to Drake's sister Daisy Molson and sister's husband, John Dunham Molson. Letters are accompanied by transcriptions and biographical material prepared by Martha E. McKenna. Also included are newspaper clippings dated 1915-1918 on Drake and the Canadian Army Medical Corps hospital run by McGill, one pocket notebook documenting Drake's time with the CAMC in France from 1915-1916, and a membership card to the Royal Club for Ladies from Beyond the Seas, dated 1919.

Fonds contains two admission cards of Harry C. Cunningham for the year 1883, one for the course of Microscope in Medicine signed by Sir William Osler and one for a six month ticket to the Montreal General Hospital.

Fonds contains correspondence, including letters and postcards from Sir William Osler, clippings and two photographs.

Fonds consists principally of one three-ring loose leaf holograph notebook written in pencil and ink. The notebook details cases that Morton worked on during the period of February to May, 1935, while at Guy’s Hospital in London. Fonds also includes a letter from real estate broker William E. Speed to Capt. W. B. Holms concerning a property rented to the Mortons; single blank leaf with letterhead of C. S. Morton (Harry Stafford Morton’s father); New Year’s card from Earle C. Phinney; and newspaper clipping of editorial by Sir William Osler, “Promethean Gift of the Century Physical Suffering Diminished.”

The fonds contains original and typescript letters, manuscript notes, newspaper clippings, journal extracts, reminiscences and more, assembled by Harvey Cushing chiefly between 1920 and 1924 during the course of his research for the biography of William Osler. For the biography, Cushing collected and retyped over 7500 pieces of Osler's correspondence, among which are some original letters.

The fonds is separated into three series: Manuscripts, Working Notes and Osler's Correspondence. It also contains photographs, annual reports, publications, clippings, one watercolor painting, one postcard. Osler's correspondence is further arranged in three subseries based chronologically.

Fonds shows Henry Beaumont Small's activities as a medical student through his admission cards for his complete medical formation. It contains 43 admission cards signed by or printed for the teachers, among them William Osler.

Fonds documents the Montreal years of H.V. Ogden and the ties he had with Sir William Osler. The fonds contains the correspondence of H.V. Ogden consisting of letters from May Francis and Marian Francis (Osborne), letters from George Cantlie, a letter from Dr. Robert Palmer Howard and a letter from Edmund J.A. Rogers.