Fonds documents Dr. F.C. MacIntosh's teaching and research activities at McGill. The fonds contains correspondence, newspaper clippings, reprints of publications, photographs, documents related to the International Union for Physiological Sciences, lectures, and student reports. The fonds also contains a dossier on Professor George Ralph Mines (1886-1914) assembled by Dr. MacIntosh from 1982-1986. The dossier includes publications, photographs, obituaries, and autopsy information of G.R. Mines, as well as correspondence regarding his death and a copy of "The short brilliant career and strange death of G.R. Mines," written by MacIntosh in 1985.

MacIntosh's involvement with the Medical Research Council of Canada is documented by correspondence, agendas and minutes (1960-1962) concerning grant applications and administrative affairs, particularly the Advisory Committee on Policy.