Albert Romain Lewis was born abt 1846 in Philadelphia, Pennsylvania.

He was a lawyer, a member of the Ontario bar. In 1862, he enlisted in the army and served during the Civil War until 1865. In 1869, he graduated from McGill University (B.A.) where he was a classmate of B.J. Harrington (1848-1907). In 1885, he served as one of the corporate executives of the Dominion Coal Company. In 1889, he became Queens Counsel.

In 1874, he married Jane Nelson Robertson. He died on December 19, 1928, in York, Ontario.

Charles Lewis, born in 1863 in Dublin, was notable for his work in pharmacy at The T. Eaton Drug Company Limited in Toronto from 1890-1917. His interest in medicine was influenced by his father, a physician and surgeon of Cork, Ireland. Lewis studied medicine at Queen's College, Cork, but his father's death made it impossible for him to finish medical school, so he turned his attention to drugs. He graduated from the University of Dublin, in the late 1880s with a major in the pharmaceutical drugs field. Upon completion of his schooling, he immigrated to Canada, settling in the Toronto area. He started his first business with Timothy Eaton, T. Eaton Company, a department store in downtown Toronto on Young Street, where he quickly added a full complement of drugs and elixirs. That was the beginning of the Chas. Lewis Drug Company. He expanded his operations to Eaton's stores and became Canada's first drugstore chain with a catalogue. In 1890, he became managing director of the T. Eaton Drug Company, a position he held until 1917, when he became head of the Welfare Department for the T. Eaton Company, Limited. He was known as "The Kindly Head of the Welfare Department." He died at his summer home "Old Mill Cottage," in Ahmic Harbour, Onatrio in 1925.

D. Sclater Lewis was born in Montreal and educated at McGill, where he received his B.Sc. (1907), M.Sc. (1908) and M.D.C.M. (1912). He taught briefly at Johns Hopkins Medical School, and joined the Canadian Army Medical Corps at the outbreak of World War I, rising to the rank of Major. After the war he joined the Faculty of Medicine of McGill University as Demonstrator in Medicine and Lecturer in Clinical Therapeutics. He became Assistant Professor in 1924, Associate Professor in 1939 and Professor in 1949. Throughout this period he was a physician at the Royal Victoria Hospital, and Acting Physician-in-Chief from 1943 to 1944. Lewis was President of a number of medical and medical-historical societies, and author of histories of the Royal College of Physicians and Surgeons of Canada and of the Royal Victoria Hospital.

Howard Jefferson Lewis, also known as H. Jefferson Lewis, and commonly Jefferson Lewis, was born in Montreal in 1951. He was the son of Crosby Lewis and Ruth Mary Penfield Lewis, the daughter of renowned neurosurgeon Wilder Graves Penfield. Lewis was educated in Europe and the United States, and graduated with a degree in Film Studies from Queen's University in 1972. He worked as a journalist for the Ottawa Citizen, Southam News Service, and CBC Radio. Following the death of his grandfather in 1976, Lewis undertook writing a biography of Penfield, which resulted in Something Hidden: A Biography of Wilder Penfield (Toronto: Doubleday) published in 1981. The biography was later turned into a screenplay and a movie produced by the Canadian Broadcasting Corporation and the National Film Board of Canada. In subsequent years, he worked as a producer and wrote and directed short dramas, whose themes frequently revolved around Canadian subjects. Lewis married Catherine Ann Keachie in 1976. The couple had one daughter, Cleo Lewis.