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Carl Winkler was born at Virden, Manitoba and educated at the University of Manitoba (M.Sc. 1931), McGill (Ph.D. 1933) and Oxford (Ph.D. 1936). After working as a biophysicist for the National Research Council of Canada, he was appointed Assistant Professor of chemistry at McGill in 1939. He was promoted to Associate Professor in 1944 and full Professor in 1946. Winkler served as Chairman of the Chemistry Department from 1955 to 1961, Chairman of the Physical Sciences Group from 1956 to 1963 and Vice-Principal (Planning and Development) from 1966 to 1969.