The fonds documents mainly Babkin's professional interests in physiology, especially glandular secretions and the nervous system. The fonds contains correspondence; lecture notes; citations; research notes and papers, including manuscripts sent to him by his colleagues; reprints of scientific articles mainly in Russian; and material used in the preparation of the biography of Ivan Pavlov. The latter contains correspondence with Ivan Petrovich Pavlov and members of his family, 1923-1948; photographs and portraits; and an unabridged typescript copy of Parts 1-3 of Pavlov: a Biography, with manuscript corrections, 1943-1946.

The Sir William Osler Collection, distinct from the Bibliotheca, is an extensive archival holding of Osler's correspondence (including eighteen hundred original letters), daybooks, accounts, engagement books, legal documents, book invoices, membership certificates, notebooks, lectures, addresses, newspaper clippings, photographs, books with manuscript additions, and miscellaneous loose items formerly inserted into individual books in his library. The collection also contains various family papers, including correspondence of Lady Grace Revere Osler and Edward Revere Osler.

Papers consist of personal correspondence, including substantial family correspondence, diaries, journals, engagement books, ledgers, menus, manuscript poems, galley proofs, lecture notes, scrapbooks, and photographs. It includes correspondence, 1874-1935; a diary of Drummond's trip to Great Britain, 1902; dinner menus, 1902-1903; engagement books, 1902-1906; galley proofs, 1905-1911; Journal of Impressions kept at Savanna la Mar, Jamaica, Windsor and Montreal, 1903-1911; lecture notes taken at McGill, 1878-1882; ledgers containing financial entries and patients' accounts during Drummond's practice in Knowlton and Montreal, 1885-1889; notebooks containing manuscripts poems, drafts and clippings, 1894-1909; scrapbooks related to literary topics, including clippings about Drummond's public readings, and book reviews, 1854-1907 and scrapbooks related to Drummond's dogs, 1890-1907. There are also some papers of Mrs. W.H. Drummond, including a typescript of her Life of W.H. Drummond; and diaries recording her trips to United States and Canada, 1892, 1903.

The collection contains private records and papers relating to the medical and teaching career of Maude Abbott. It consists in large part of correspondence, 1894-1920, including family correspondence with, among others, her sister Alice Abbott, 1904-1919, and her brother Rev. Harry M. Babin, 1916-1920. Also included are manuscripts and drafts of articles and addresses; case reports; post-mortem records; glass slides and drawings; exhibit panels largely pertaining to her research on congenital heart disease; programmes of medical meetings, 1902-1937; reprints and papers relating to the history of medicine in Montreal and Quebec, as well as to the history of McGill, 1829-1936. In addition, there are photographs, some poems, an autobiographical sketch and a printed copy of her Classified and Annotated Bibliography of Sir William Osler's Publications, 1939, with corrections and annotations by W. W. Francis. Fonds also includes a draft of Abbott's letter to the Dean of Faculty of Medicine, McGill University, regarding admission (1889).

The collection contains correspondence, curriculum vitae, a poem written by his wife, Elizabeth Turnor, a record of medical examinations for the Coroner's Court of Montreal, 1894 and lectures notes. The greater part of the notes consists of embryology notes made at the Anatomisches Institut, Munich, around 1900.

Fonds documents Burton Chance's links with Casey A. Wood from 1922 until Wood's death in 1942. The fonds contains correspondence between the two men, reprints of C.A. Wood and letters from various correspondents concerning C.A. Wood.

Fonds contains Dr. M.H.F. Friedman's personal papers and files relating to Dr. Boris P. Babkin and also correspondence with the editor of Babkin's biography of I.P. Pavlov.

The fonds consists of Dr. Bensley's research notes and correspondence, particularly in relation to his publication McGill Medical Luminaries.

The fonds contains letters, 1948-1958, to and from Dr. W.W. Francis. It also includes two poems by Francis, and a letter from the Dean of the Faculty of Medicine regarding death of Francis in 1959.

The fonds contains materials that Dr. M. Entin collected for his biography of Dr. Archibald. Mainly include articles relate to tuberculosis, pancreatitis, wound healing, history of surgery, and scientific writing. It also includes letters from Edward Archibald to Mrs. Archibald, letters to Archibald from William Osler and Sir Henry Gray, addenda of Archibald's world journey in 1936, and articles by Archibald.

Some draft chapters of the biography of Dr. Archibald and research data for 100th Anniversary of Royal Victoria Hospital can also be found in the fonds.