The fonds contains original and typescript letters, manuscript notes, newspaper clippings, journal extracts, reminiscences and more, assembled by Harvey Cushing chiefly between 1920 and 1924 during the course of his research for the biography of William Osler. For the biography, Cushing collected and retyped over 7500 pieces of Osler's correspondence, among which are some original letters.

The fonds is separated into three series: Manuscripts, Working Notes and Osler's Correspondence. It also contains photographs, annual reports, publications, clippings, one watercolor painting, one postcard. Osler's correspondence is further arranged in three subseries based chronologically.

Fonds shows Dr. Philip Franklin's relations and activities with Sir William Osler regarding the Post-Graduate Scheme in England and the American Hospital in England during WWI. The fonds contains letters, telegrams and an agenda and printed material regarding a meeting about the American Hospital.

Fonds contains the notebook kept by Walker Herbert Drury of his bacteriology laboratories while a student at McGill University, from 1906 to 1908, but mainly 1906.

Fonds consists of letters and accompanying reports from John J. Robson, Superintendent of the Royal Victoria Hospital, concerning staffing in the hospital and changes to bylaws. Also included is a letter from Dr. R. P. Boucher of Peterborough, ON, to Buller introducing Boucher’s friend Dr. Halliday.

The fonds contains four original manuscript diaries (1 per calendar year), from 1889 to 1991 (transatlantic) with original watercolor drawings by John Henry Wye, Allan Line ship’s surgeon.

The fonds documents John Bell's activities related to his medical studies at McGill in Surgery, Materia Medica and the Institutes of Medicine, as well as his work as a private physician in Montreal. The fonds consists of notebooks, a photocopy of his MS McGill medical thesis, letters from his personal and professional life, one of his medical kits, receipts from merchants, various subscriptions, societies and clubs. The fonds also contains various reprints of Bell's articles, including the 1878 article, "Case of Diphtheria, Acute Laryngeal Symptoms", as well as the City of Montreal's "Mortality of Montreal" – a list of all deaths in Montreal in January 1878.

Fonds contains the letters of certification of William A. De Wolf Smith's attendance at medical courses at McGill University in 1883. The fonds includes three letters of certification signed by teachers.

Fonds contains lecture notes taken by Robert Struthers at McGill Medical College in 1881-1882, including notes on Pathology, Surgery and Ophthalmology. Lecturers include Robert Palmer Howard, Sir Thomas Roddick and Sir William Osler. There is also a case report by Struthers. The fonds includes two notebooks and a case report.

Fonds consists of a notebook dated October 1875 of lecture notes by Arthur Adderly Browne pertaining to midwifery in Ontario.