Fonds contains "The journal of an English lady; or letters descriptive of the continent during the years 1829 and 1830" to which have been added water-colour illustrations by the author.

The collection consists of ephemera, artifacts, and publications related chiefly to the Expo 67 World Fair in Montreal and some documents relating to its continuation, Man and His World (Terre des Hommes), an exhibition that was the successor to Expo 67. Many of the records and artifacts were produced by participant countries and sponsors or by the Canadian Corporation for the 1967 World Exhibition. Ephemera includes postcards, visitor passports, and ticket stubs, while other textual documents include guidebooks, magazines, catalogues, books, clippings, information manuals, and some unpublished planning documents. Artifacts include license plates, vinyl records, letter opener, bottle caps, shopping bags, and pins. The collection features pamphlets and brochures for numerous pavilions, events, services, and countries featured, as well as many maps for the Expo 67 grounds and documents related to subsequent seasons of Man and His World.

Approximately half this material consists of letters, covering the years 1823-1837, from Andrew William Cochran, 1792-1849, civil secretary to the governors of Lower Canada from 1812 onwards, and a member of the Executive Council from 1827 to 1841. The remainder comprises a number of accounts of travels and exploration by North West Company employees, probably collected by McKenzie for his history. Included are Charles McKenzie's expeditions amongst the Otoe Missouria Tribe.; Edward Umfreville's journal of a canoe trip from Lake Superior to Portage de l'Isle 1784; accounts of the Alaskan Athabaskans, 1795 and 1805, George Keith's memoirs of the McKenzie River Department, 1807-1817; and George Henry Monk's of the Department of Fond du Lac or Mississippi, 1807; John McDonnell's account of the Red River, ca 1787; and John Johnston's of Lake Superior and a letter on the Indigenous communities of the northwest from Eneas McDonnell. Also included are letters written to McKenzie from Forks on the Mackenzie River by William Ferdinand Wentzel, 1807-1824.

Macdonell's papers comprise a journal for 1793-1795, which L.R. Masson entitled "Assinoboines-Rivière Qu'appelle", and an account of the Red River, approximately 1797.

The collection consists of documents pertaining to Dr. H. S. Birkett's medical activities, including 117 bound volumes of patient records (1889-1942), medical notebooks (1893-1896), bound RVH reports (1894-1938), RVH charts (1901-1920) and registers (1899-1917). There are also various letters addressed to Mr. and Mrs. Birkett, a manuscript, newspaper clippings, various degrees and medical association certificates, as well as photographs of H. S. Birkett's personal life and professional life at McGill and elsewhere. The collection also includes various artifacts collected by H. S. B, including military and medical memorabilia collected by H. S. Birkett.

The fonds contains the professional papers of Canadian-American architect Witold Rybczynski. They comprise textual records including book manuscripts and proofs, research materials, reviews, correspondence, and teaching material, as well as slides and digital files representing his career as an author and educator.

The Harold Spence-Sales fonds at McGill’s Canadian Architecture Collection primarily contains project records related to Harold Spence-Sales' career as an architect and urban planner. The bulk of the records pertain to projects that Harold Spence-Sales worked on as well as corresponding financial, administrative and office records.

The fond heavily documents projects that Harold Spence-Sales worked on during the 1970s-1980s in British Columbia and in Quebec during the 1940s-1960s. Other projects that Harold Spence-Sales worked on across Canada and internationally appear intermittently throughout the fonds. The Oromocto community planning project that Harold Spence-Sales worked on from 1955-1958 in New Brunswick is particularly well documented. Harold Spence-Sales designed Oromocto to be a military town. Before He transformed Oromocto into a military town it was a defunct 19th century shipbuilding town. The Oromocto project is considered one of Harold Spence-Sales most important urban-town planning projects.

Apart from administrative, office and project records, the fonds also contains records that relate to Harold Spence-Sales professional activities outside of his work as an architect and urban planner. For example, awards and honors that he received and records related to his involvement in architectural and urban planning associations. Additional professional activities include: his involvement in creating exhibitions, curating architectural-themed magazines and periodicals as well as copies of publications that he worked on solo and in collaboration with John Bland.

The fonds also contains fourteen boxes of Harold Spence-Sales personal records. The personal records primarily cover Harold Spence-Sales interest in art, creative pursuits, family activities, family genealogy, personal finances, last will and testaments as well as his decline in health and his death. Within the fourteen boxes that have been cataloged as personal records, there are also materials related to Harold Spence-Sales professional activities. For example, awards that Harold Spence-Sales received and records related to exhibitions and artistic projects that he worked on.

The fonds consists of textual records and artifacts related to surgeon and researcher Dr. Charles R. Drew. It contains letters, artifacts, and a yearbook from Drew's time as a student at McGill University, including his notable achievements as a student athlete. These items include medals, a track meet program, an athletic shirt, and a yearbook. The fonds also contains invitations, pamphlets, and other ephemera related to tributes and honors awarded to Drew, including printed testimonials and materials associated with schools, lectures, and institutions named after him, such as the Charles R. Drew Postgraduate Medical School. These tributes and honors primarily recognize his contributions to medical science, but also encompass the program from his induction into the McGill Athletics Hall of Fame. Two letters in the fonds addressed to Drew's sister and his wife reflect on his accomplishments and include reminiscences from friends. Additionally, the fonds comprises five reprints of articles authored by Drew and two items concerning his career at Howard University and the Freedman's Hospital, including an outline for gathering a patient's medical history.

The fonds consists chiefly of student notebooks kept by F. Clarke Fraser while an undergraduate at Acadia University during the late 1930s-1940. They represent a variety of subjects, including zoology, physics, mathematics, and biology. Two notebooks date from his Med IV year (1949-1950) at McGill University’s Faculty of Medicine, one with ophthalmology lab and clinical notes and reading and lecture notes, and one an obstetrical diary from the Montreal Maternity Hospital. Also included is a later reprint of an article (published 1957), loose notes, and a photograph of F. Clarke Fraser and a companion dining at the Montreal restaurant Au lutin qui bouffe, famous for its resident piglet, which restaurant-goers were often photographed holding and feeding.