The fonds contains ledgers, legal documents, permits, one scrapbook, and photographs.

The fonds consists of Dr. Roland's files principally in relationship to his research on Sir William Osler and to his activities in the American Osler Society

The fonds contains survey procedures, correspondence, reports, proofs and drafts of the final report.

The fonds contains one prescription book of Dr. Robert Todd Reynolds, with some clippings of medical drawings in the back; 3 pages of the Reynolds' family genealogy record and one page of an article "The Ancestral Roof: Domestic Architecture in Upper Canada" and a photo of the house, indicating the relationship between James McGill des Rivières and the Reynolds family; 4 of R. T. Reynolds' Diplomas, one from McGill.

The fonds contains materials that Dr. M. Entin collected for his biography of Dr. Archibald. Mainly include articles relate to tuberculosis, pancreatitis, wound healing, history of surgery, and scientific writing. It also includes letters from Edward Archibald to Mrs. Archibald, letters to Archibald from William Osler and Sir Henry Gray, addenda of Archibald's world journey in 1936, and articles by Archibald.

Some draft chapters of the biography of Dr. Archibald and research data for 100th Anniversary of Royal Victoria Hospital can also be found in the fonds.

The fonds contains four original manuscript diaries (1 per calendar year), from 1889 to 1991 (transatlantic) with original watercolor drawings by John Henry Wye, Allan Line ship’s surgeon.

The fonds contains fourteen notebooks kept by the Poisson family during their studies in medicine. The notebooks contain lecture notes and class notes on various topics in medicine taught by prominent professors such as, Jean Étienne and L. Landry, L. Simard, F.A.H. Larue, and J. Sewell.

The fonds contains correspondence related to the Osler Library and its holdings with people such as Maude Abbott, Edward Archibald, William B. Bean, Edward Horton Bensley, Archibald Malloch, Casey Wood, as well as John Farquhar Fulton, Keeper of the Medical History Collections at Yale University's library; the fonds also contains a typescript of talks by W.W. Francis (titled "Showman's Patter") about books and other items held in the Osler Library.

The fonds includes two McGill University hand-books, 1913-1914 and 1914-1915 with brief notes referring to his activities as a student; three booklets of notes taken in Embryology, [191?], Histology, 1914 and one [unspecified] booklet of notes, [191?]. A newspaper clipping from the Chronicle: “The Kaiser and the Lusitania: Torpedoed against his wishes,” August 13, 1917; inventory from the Imperial War Museum of “The Papers of Mrs. G. S. Prichard” (mother to Prichard) relating to the correspondence between Mrs. Prichard and survivors of the Lusitania in search for news of her son during the sinking; Royal Bank of Canada Pass Book from Ewing, Alberta with records of Prichard’s cheque book activities from 1912-1914; a letter detailing investments (on McGill letterhead) dated January 22, 1914, is included inside the Royal Bank Pass Book.

Fonds contains various certificates and awards received by Browne; photographs and slides; two official portraits; letters of Ms. W. Browne (sister) regarding Browne; Last Will and Testament; The Canadian Medical Hall of Fame Induction Ceremony VHS, and newspaper clippings.