The collection contains the Holmes Gold Medal, photographs, certificates, a poem, letters, newspaper clippings and memoirs.

The fonds contains correspondence concerning a dinner in honour of Sir William Osler at the University Club, New York, organized by Beverly Chew, M. Taylor Pyne, Edward G. Kennedy, William Augustus White, Frederick R. Halsey and Ernest Dressel North in 1913. The fonds includes 74 original letters. E.D. North managed the correspondence for the event, which included numerous bibliophiles.

Papers consist of personal correspondence, including substantial family correspondence, diaries, journals, engagement books, ledgers, menus, manuscript poems, galley proofs, lecture notes, scrapbooks, and photographs. It includes correspondence, 1874-1935; a diary of Drummond's trip to Great Britain, 1902; dinner menus, 1902-1903; engagement books, 1902-1906; galley proofs, 1905-1911; Journal of Impressions kept at Savanna la Mar, Jamaica, Windsor and Montreal, 1903-1911; lecture notes taken at McGill, 1878-1882; ledgers containing financial entries and patients' accounts during Drummond's practice in Knowlton and Montreal, 1885-1889; notebooks containing manuscripts poems, drafts and clippings, 1894-1909; scrapbooks related to literary topics, including clippings about Drummond's public readings, and book reviews, 1854-1907 and scrapbooks related to Drummond's dogs, 1890-1907. There are also some papers of Mrs. W.H. Drummond, including a typescript of her Life of W.H. Drummond; and diaries recording her trips to United States and Canada, 1892, 1903.

Fonds documents Dr. Antonio Cantero's professional activities, especially his cancer research. The fonds contains correspondence, notes, reports, printed matter, slides, photographs and films.

Fonds shows Dr. D. Sclater Lewis' medical and medical-historical activities, from 1904 until his death. The fonds contains correspondence, lecture notes and notes for addresses and published papers.

Fonds documents Dr. H.E. MacDermot's medical-historical activities. The fonds contains newspaper clippings, manuscript notes, photographs, lectures notes, and a draft of The MGH, the Years of Change.

Fonds documents the Mallochs' activities related to their medical and literary work. The fonds contains notes, correpondence, commonplace books, account books, material related to publications, family memorabilia, scrapbooks, photographs, telegrams, postcards and certificates.

Fonds documents Dr. Oscar Emery Morehouse's involvement with his alma mater, McGill University. The fonds contains admission tickets, programmes, newspaper clippings, receipt, examination paper,menus and invitation cards.

The fonds largely document Dr. Segall's professional activities as a cardiologist. It contains correspondence, notes, experimental notebooks, lecture notes, articles, speeches, patients' records, electrocardiograms, reprints and material pertaining to the Louis Gross Memorial Lectures, 1922-1979. Also included are several electrocardiograph machines, dictation devices, and audio recordings (reel-to-reel tapes, dictation disks, and cassette tapes). In addition, the fonds contain records of Dr. Segall's personal and family correspondence, financial transactions, and various other official and unofficial documents.