Fonds documents the Mallochs' activities related to their medical and literary work. The fonds contains notes, correpondence, commonplace books, account books, material related to publications, family memorabilia, scrapbooks, photographs, telegrams, postcards and certificates.

Fonds shows Dr. Philip Franklin's relations and activities with Sir William Osler regarding the Post-Graduate Scheme in England and the American Hospital in England during WWI. The fonds contains letters, telegrams and an agenda and printed material regarding a meeting about the American Hospital.

Fonds documents the friendship between Mrs. Alice Russel and Dr. Abraham Flexner. It also includes documents collected by Mrs. Russel on Sir William Osler and Maude Abbott. The fonds contains correspondence and newspaper clippings.

Fonds documents Dr. F.C. MacIntosh's teaching and research activities at McGill. The fonds contains correspondence, newspaper clippings, reprints of publications, photographs, documents related to the International Union for Physiological Sciences, lectures, and student reports. The fonds also contains a dossier on Professor George Ralph Mines (1886-1914) assembled by Dr. MacIntosh from 1982-1986. The dossier includes publications, photographs, obituaries, and autopsy information of G.R. Mines, as well as correspondence regarding his death and a copy of "The short brilliant career and strange death of G.R. Mines," written by MacIntosh in 1985.

The fonds contains the manuscript of his book William Osler : A Life in Medicine.