The fonds consists of textual records and artifacts related to surgeon and researcher Dr. Charles R. Drew. It contains letters, artifacts, and a yearbook from Drew's time as a student at McGill University, including his notable achievements as a student athlete. These items include medals, a track meet program, an athletic shirt, and a yearbook. The fonds also contains invitations, pamphlets, and other ephemera related to tributes and honors awarded to Drew, including printed testimonials and materials associated with schools, lectures, and institutions named after him, such as the Charles R. Drew Postgraduate Medical School. These tributes and honors primarily recognize his contributions to medical science, but also encompass the program from his induction into the McGill Athletics Hall of Fame. Two letters in the fonds addressed to Drew's sister and his wife reflect on his accomplishments and include reminiscences from friends. Additionally, the fonds comprises five reprints of articles authored by Drew and two items concerning his career at Howard University and the Freedman's Hospital, including an outline for gathering a patient's medical history.

The fonds consists chiefly of student notebooks kept by F. Clarke Fraser while an undergraduate at Acadia University during the late 1930s-1940. They represent a variety of subjects, including zoology, physics, mathematics, and biology. Two notebooks date from his Med IV year (1949-1950) at McGill University’s Faculty of Medicine, one with ophthalmology lab and clinical notes and reading and lecture notes, and one an obstetrical diary from the Montreal Maternity Hospital. Also included is a later reprint of an article (published 1957), loose notes, and a photograph of F. Clarke Fraser and a companion dining at the Montreal restaurant Au lutin qui bouffe, famous for its resident piglet, which restaurant-goers were often photographed holding and feeding.