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This series contains several of Dr. Penfield's personal appointment diaries, and several diaries of his wife, Helen Kermott Penfiedl. It also currently includes a photograph album from 1913-1916, a scrapbook from Dr. Penfield's time at Galahad School (1905), some miscellaneous material collected by Dr. William Feindel concerning Dr. Penfield and the Montreal Neurological Institute, and an old reprint mailing list compiled by Dr. Penfield.

Sub-series consists of bound appointment diaries used by Dr. Penfield to kep track of both his personal and professional engagements between 1930 and 1976.