The collection contains correspondence, curriculum vitae, a poem written by his wife, Elizabeth Turnor, a record of medical examinations for the Coroner's Court of Montreal, 1894 and lectures notes. The greater part of the notes consists of embryology notes made at the Anatomisches Institut, Munich, around 1900.

The collection contains private records and papers relating to the medical and teaching career of Maude Abbott. It consists in large part of correspondence, 1894-1920, including family correspondence with, among others, her sister Alice Abbott, 1904-1919, and her brother Rev. Harry M. Babin, 1916-1920. Also included are manuscripts and drafts of articles and addresses; case reports; post-mortem records; glass slides and drawings; exhibit panels largely pertaining to her research on congenital heart disease; programmes of medical meetings, 1902-1937; reprints and papers relating to the history of medicine in Montreal and Quebec, as well as to the history of McGill, 1829-1936. In addition, there are photographs, some poems, an autobiographical sketch and a printed copy of her Classified and Annotated Bibliography of Sir William Osler's Publications, 1939, with corrections and annotations by W. W. Francis. Fonds also includes a draft of Abbott's letter to the Dean of Faculty of Medicine, McGill University, regarding admission (1889).

The Sir William Osler Collection, distinct from the Bibliotheca, is an extensive archival holding of Osler's correspondence (including eighteen hundred original letters), daybooks, accounts, engagement books, legal documents, book invoices, membership certificates, notebooks, lectures, addresses, newspaper clippings, photographs, books with manuscript additions, and miscellaneous loose items formerly inserted into individual books in his library. The collection also contains various family papers, including correspondence of Lady Grace Revere Osler and Edward Revere Osler.

Frobisher's papers comprise a letterbook of the North-West Co. containing copies of letters written by Frobisher from April 1787 to October 1788, two original letters to Simon McTavish, 1796, and one from him, 1787, business and legal documents, largely concerning the estate of James McGill, 1810-1834, and a diary, 1806-1810, mostly a record of where he dined.

There is business correspondence, 1792-1800, with letters from among others Alexander Mackenzie, Joseph Frobisher, Alexander Henry, Simon Fraser and Roderick Mackenzie. There are also minutes and resolutions of the Executors of McTavish in a bound volume; and a contemporary copy of the minutes of the executors of his will, 1805.

This collection consists of contemporary copies of letters written by T. Blackwood from Michilimackinac to James and Andrew McGill & Co., to Ch. Chaboillez, and to T. and J. McGregor.

This collection reflects Henry S. Chapman's relationships with a number of important figures in Montreal's political and business history, between roughly 1833 and 1853, the period following Chapman's return to London. A significant amount of the material in this collection is related to the 1837-1838 Upper and Lower Canada Rebellions (especially in Montreal), as well as events occurring immediately after the uprisings.

Consists of copies of original material, chiefly correspondence, arranged roughly by date. The contents of letters (1835-1853) include business partnerships, political reform, and personal news. Significant correspondents include Louis-Joseph Papineau, Louis-Hippolyte La Fontaine, Jacob Dewitt, François-Antoine Larocque (of Laroque and Bernard), Joseph Perreault, and Edmund Bailey O’Callaghan. There is also a partial manuscript on Canadian history and pages from a scrapbook, both dating from the 1830s.

This collection consists of translations from Terence, begun in 1778, and correspondence on military, political and private matters, 1787-1821, mostly addressed to Thomas Coutts, banker.

Letters and diaries, including typescript transcriptions with photographs, newspaper clippings and ephemera.

Consists of an English translation of a letter to the Marquis de la Jonquière written by Antoine-Louis Rouillé, comte de Jouy, secretary of state for the French Navy, at Versailles, dated 28 February 1750. The letter discusses an immediate release of prisoners of war taken during conflicts between the French and British colonies. It also includes a mention of Indigenous allies of England and France, and Indigenous people captured during the conflicts: "the Indian Prisoners among the two Nations be likewise released, but after all the French and English Prisoners are released" The letter also includes the name of examiner Josiah Willard, secretary of the province of Massachusetts-Bay.