The fonds contains original and typescript letters, manuscript notes, newspaper clippings, journal extracts, reminiscences and more, assembled by Harvey Cushing chiefly between 1920 and 1924 during the course of his research for the biography of William Osler. For the biography, Cushing collected and retyped over 7500 pieces of Osler's correspondence, among which are some original letters.

The fonds is separated into three series: Manuscripts, Working Notes and Osler's Correspondence. It also contains photographs, annual reports, publications, clippings, one watercolor painting, one postcard. Osler's correspondence is further arranged in three subseries based chronologically.

Fonds contains a manuscript, entitled "Remarks on the Osteology of Alexander Monro by himself", written by Dr. John George Bethune who transcribed an old damaged manuscript found in a trunk in the garret of the steam factory of Bethune's father in August 1848. The damaged manuscript was, according to Bethune, from one of three famous physicians, three successive generations of an Edinburgh family, who all bore the name Alexander Monro.

Fonds documents Dr. H.E. MacDermot's medical-historical activities. The fonds contains newspaper clippings, manuscript notes, photographs, lectures notes, and a draft of The MGH, the Years of Change.

The fonds contains the manuscript of his book William Osler : A Life in Medicine.

Fonds contains the manuscript of Dr. William Rees on the treatment of malaria, a lecture given before the Natural History Society of Montreal in the 1860s

Fonds documents a portion of the literary activities of Sir Andrew Macphail with the typescript of In Flanders Fields and Other Poems by Lieut.-Col. John McCrae M.D. with the Essay in Character by Sir Andrew Macphail, originally published in 1919. The typescript is accompanied by a signed letter from Macphail. The fonds also contains a letter from John McCrae while on active duty in France to Carleton Noyes, Cambridge, MA, with an envelope postmarked 31 May 1916. Enclosed with the letter is an autographed signed copy of McCrae's poem, In Flanders Fields.

Fonds documents Dr. Alton Goldbloom's professional activities, mainly his writings on pediatrics. The fonds contains diplomas, notice of appointment, correspondence, notes, reprints, manuscripts of I'm on Your Side, Small Patients, and revised text of Le soin de l'enfant.

Fonds consists of the personal and professional papers of Louis and Irene Kon including extensive correspondence between the Kon family. Included are materials relating to the founding of the Norman Bethune Foundation and Bethune memorials; the making of Ted Allan's movie, "Making of a Hero", including the conflict with Syd Gordon regarding creative differences; a manuscript draft and notes on Larry Stephenson's manuscript 'Two Petrals.'

The collection consists of documents pertaining to Dr. H. S. Birkett's medical activities, including 117 bound volumes of patient records (1889-1942), medical notebooks (1893-1896), bound RVH reports (1894-1938), RVH charts (1901-1920) and registers (1899-1917). There are also various letters addressed to Mr. and Mrs. Birkett, a manuscript, newspaper clippings, various degrees and medical association certificates, as well as photographs of H. S. Birkett's personal life and professional life at McGill and elsewhere. The collection also includes various artifacts collected by H. S. B, including military and medical memorabilia collected by H. S. Birkett.

The fonds includes Dr. Archibald’s correspondence and reports pertaining to the Ministry of National Defence, 1940-1945; certificates and diplomas; and a photograph. The correspondents include family members, Dr. John McCrae and Sir William Osler. There is also a draft of a book on wound ballistics and gas gangrene; an Army Field Service book, 1916 and two notebooks on internal and external pathology, “matiere medicale et therapeutique,” and “medecine legale et toxicologie,” 1895.