This series includes records of events, biographical and historical data, and many visual materials. Much of this material is ephemeral and was originally found in Dr. Penfield and Mrs. Penfield's boxes of memorabilia. The series is divided into 15 subseries, each of which may be grouped into two divisions: general and personal (indicated by addition of WGP to file identifier).

This series consists of the manuscripts, and related materials, of Dr. Penfield's published and unpublished writings.

This series consists of records generated by Dr. Penfield as an employee of McGill University or the Montreal Neurological Institute. Most of the material in this series is the property of those institutions, and is not considered personal material.

This series consists of most of Dr. Penfield's correspondence. The series is composed of three sub-series corresponding to Dr. Penfield's "Simple System." (C = Correspondence)

This series consists of objects or artifacts that belonged to Dr. Penfield.

Series consists of miscellaneous material produced and collected by Dr. Penfield. This series includes art work, notes, and correspondence, as well as Dr. Penfield's academic robes and hats. This includes copies of the French 'Bulletin de l'Académie Royale de medecine', 'Bulletin de l'Académie nationale de medecine' and 3 editions of the Montreal La Lancette Canadienne journal. The series also includes less than 1 cm of photographs (found in file J 13-1), a framed diploma (file J 2-3) and selections for an exhibit from 1991 by William Feindel.

The series is comprised of personal and appointment diaries, recording Dr. Penfield's work engagements, personal thoughts, and travels between 1904 and 1976. The series also includes two scrap books and several diaries by Dr. Penfield's wife, Helen Kermott Penfield.

Series consists of a drawer of catalogue cards with information concerning most MNI Fellows from between the institute's opening to the 1970s. Much of this information consists of mailing addresses which were compiled in the late 1970s and early 1980s, and is thus likely no longer accurate. Many of the cards are also accompanied by photographs of the particular Fellow.

Series consists of notes produced by Dr. Penfield on books and articles he had read.

This series contains a group of calendars, or diaries, kept by Dr. Penfield's wife between 1947 and 1974.